Based on the fixed dose volume, cats weighing less than 3 kg were overdosed (125 Cg/kg M, 12.5
mg/kg K, 12.5 Clg/kg B) on average by 25% for MKB. The smallest cat weighed 1.8 kg. Based
on the fixed dose, this cat was overdosed (166 Clg/kg M, 16.6 mg/kg K, 16.6 Clg/kg B) as well.
This represents a 66% increase in the amount of MKB given in excess. Approximately 30% of
cats (n = 11) weighed over 3.0 kg. The average weight for cats weighing > 3 kg was 3.56 & 0.4
kg. Cats weighing over 3 kg were under dosed (84 Clg/kg M, 8.42 mg/kg K, 8.42 Clg/kg B) by -
16% .
Seven cats (2 males, 5 females) needed an additional injection (0.1 mL; 0.043 mg M, 4.3
mg K, 0.0042 mg B) of MKB. Four of the 7 cats that required an additional inj section of MKB
weighed > 3.0 kg. Similarly, 7 cats (2 males, 5 females) required an additional inj section of the
reversal agent atipamezole, including 3 cats (1 male, 2 females) that received a second dose of
MKB. One female cat required a third inj section of atipamezole approximately 2 hours following
the initial atipamezole injection. That cat achieved sternal recumbency approximately 10 minutes
following the third inj section of atipamezole.
Phase 3-Fixed Dose Study (0.7 mL): Time Intervals
Time to lateral recumbency was 7 & 5 minutes and 4 & 3 minutes in males and females,
respectively. Surgical duration was longer in females (43 A 18 minutes) than in males (7 & 4
minutes). Time from reversal to sternal recumbency was 31 & 20 minutes in males and 31 & 31
minutes in females. Total time recumbent was 64 & 20 minutes and 117 & 46 minutes in males
and females, respectively.
Phase 3-Fixed Dose Study (0.7 mL): Side Effects
Apnea or severe respiratory depression was observed in several cats (n = 6). The weight
of these cats (4 females, 2 males) was 2.9 & 0.5 kg (M: 2.9 kg, R: 2.34-3.9 kg). One cat vomited
following inj section of MKB.