TABLE OF CONTENTS


 page

ACKNOWLEDGMENT S .............. .................... iv


LI ST OF T ABLE S ............ ...... .___ ............... vii...


LIST OF FIGURES ........._.._.._ ....__. ..............viii...


AB STRAC T ................ .............. ix


CHAPTER


1 INTRODUCTION ................. ...............1.......... ......


2 IVETHODS .............. ...............7.....


 Animal s............... ...............7.

 Surgical Procedures .............. ...............8.....
 Experimental Procedures .................. ........... ...............8.......
 General Social Defeat Stress Procedure ................. ............. ......... .......8
 Social Defeat Stress Regimen: Experiment la............... ...............9...
 Social Defeat Stress Regimen: Experiment lb............... .. ...............10
 Social Defeat Stress and Porsolt Swim Test: Experiment 2 ............... ... ............11
 Behavioral Assays .............. ...............12....
 Histological As says .............. ...............12....
 Statistical Analyses ................. ...............13.................

3 RE SULT S ................. ...............17.......... .....


 Experiment la: Six Daily Sessions of Social Defeat Stress .............. ....................17
 Experiment lb: Twelve Intermittent Sessions of Social Defeat Stress .....................23
 Experiment 2: Social Defeat Stress Followed by Porsolt Swim Testing...................27
 Inter-Ob server Reliability ................. ...............27................

4 DI SCUS SSION ................. ...............29................


 Daily Social Defeat Stress .............. ...............29....
 Intermittent Social Defeat Stress .............. ...............30....
 Relevance to Previous Work .............. ...............3 1....