recognition sites with predetermined selectivity enable MIPs to rebind selectively the original

template from a mixture. In principle, MIPs can be made with selectivity for essentially any of a

diverse range of analyte species, such as drug enantiomers, pesticides, hormones, toxins, short

peptides, and nucleic acids.75s


Figure 1-9. Outline of the molecular imprinting strategy.

 Many parameters can affect the efficiency of the synthetic molecularly imprinted polymers

such as the porogen (solvent), the polymerization technique, and also the relative concentrations

of the functional monomer, cross-linker, template molecule, and initiator. Figure 1-10 shows

examples of classical functional monomers and cross-linkers commercially available for radical

polymerization.8





 -O


 Functional monomers

 i~ CHa~ 0 CH

 0 CH, OCH,
 Crosslinkers

Figure 1-10. Examples of commercially available functional monomers and cross-linkers.8