U


I one flanking Cl
EC: two flanking Cl


 0 3,4 2,4,6 2,3,4,5 2,3,5,6
Substitution pattern on nonphenol ring


 Sone flanking Cl
..I~ two flanking Cl


40001

30001

2000-

1000-


~I


 03,4 2,4,6
Substitution pattern on


2,3,4,5 2,3,5,6
nonphenol ring


Figure 4-4. Decrease in Vmax with addition of second chlorine atom flanking the phenolic
 group, while keeping the chlorine substitution pattern on the nonphenolic ring
 constant.


A) proximal intestine. B) liver.


I