TABLE OF CONTENTS page A C K N O W L E D G M E N T S ................................................................................................. iii LIST OF TA BLE S .............. ............ ... ........... .. ........... .............. .. vii LIST OF FIGURES ............. .. ..... ...... ........ ....... .......................... viii A B ST R A C T ................. .......................................................................................... x CHAPTER 1 IN TR OD U CTION ............................................... .. ......................... .. B a ck g ro u n d ............................................................................................ ....... ..... . Significance and H ypotheses ............................................................... ............... 12 2 M ETHOD S ..................................... ................................. ........... 14 P participants ................................ .................. ...... ............ .... ........ 14 Clinical Assessment of Parkinson's Disease Severity..............................................15 Videoradiography ............. .... ............. .................... .. .......... .......... 16 Data Analysis ..................................................... 18 M easurem ents Related to Sw allow Tim ing.................................. .................... 18 Measurements Related to Penetration/Aspiration ................... .............. 19 M easurem ents of Hyoid M otion........................... .................... ............... 20 M measures of Quality of Life ...... ............................................... ............... 21 S statistic s .......................................................................... 2 2 P rim ary A im ................................................................2 2 Exploratory Study ......................................................... .. ......22 3 R E S U L T S .............................................................................2 3 P rim a ry A im ............................................................................................................... 2 3 R e liab ility ................................................................2 4 Statistical A naly sis ...........................................................24 Exploratory Study: Hyoid Trajectory Measurements ..............................................28 R e liab ility ................................................................2 8 Statistical A naly sis ...........................................................2 8 Case Studies................... ......... .. .... .... .............. ...30 v