In chapter 4, N-acylbenzotriazole is introduced as neutral acylating reagents for the

preparation of primary, secondary, and tertiary amides. Reaction of N-acylbenzotriazoles

with various amines under mild conditions is discussed.

 In chapter 5, syntheses of di-, tri-, and tetra-peptides is demonstrated utilizing N-(Z-

aminoacyl)benzotriazoles with unprotected amino acids in aqueous solution. N-(Z-

Aminoacyl)benzotriazoles are prepared from N-Z-amino acids and an intermediate

obtained by reaction of 1H-benzotriazole and thionyl chloride.

 In chapter 6, N-acylbenzotriazoles are applied to C-acylation under Friedel-Crafts

conditions using heterocyclic compounds such as pyrrole, N-methylpyrrole, indole, N-

methylindole, 2-methylfuran, and thiophene. This method provides heteroaromatic

ketones, and is especially useful when the acid chlorides corresponding to N-

acylbenzotriazoles are not readily available.