assisting me during my committee meetings when discussions of fluorescence started to go over my head. I would also like to take the time to thank everyone that I had the pleasure of working with in the lab. These are the people I spent countless hours with during the course of the day and held many scientific and personal conversations with, and I am happy to be able to call them my friends. I could not have spent the last five years with a better group of people. Drs. Tammy Otto and Debra Zies were members of the lab when I first j oined and were the ones who taught me the ways of the lab. Dr. Michelle Gumz joined the graduate program and subsequently joined Dr. Cain's lab the same time as I. I would like to thank Tammy, Debbie and Michelle for their scientific and personal support as well as sharing with me memories of pool barbeques, wedding showers and baby showers. Dr. Deepa Bhatt joined the lab as a postdoc during my graduate career. Her friendship and scientific guidance have been very valuable to me. I would like to thank her for giving me fantastic advice on all of my oral presentations and reviewing all of my papers. And finally, I would like to thank my family for all the encouragement, love and support they have unwaveringly offered over the years. I would like to thank my dad for always finding the positive in everything that was negative and always encouraging me to overcome the many obstacles that graduate school hurled towards me. He never lost faith in me, even when I was ready to give up. I would like to thank my mom for her tremendous support as well. She spent a lot of time and energy stocking my refrigerator and freezer full of meals when I found that I did not have the time to care for myself. She has spent many weeks and weekends at my home since my daughter was born so that I