staining of the specimens was mainly concentrated in the cytoplasm of epithelial and

endothelial cells.

 All studied sections were stained positive for IGF-1 receptor (see figure 3-2).


Figure 3-2: Positive Immunoreactivity


Table 3-1. Distribution of Data
 Total number
 Grade I Grade II Grade III of samples
Diabetic 2 2 4 8
Non-diabetic 6 3 5 14
Total number of slides graded (n = 22)


 Although there seems to be a trend for diabetic gingival tissue samples to have a

greater (grade III) stain intensity distribution as well as a trend for non-diabetic gingival

tissue samples to have a weaker (grade I) stain intensity (Table 3-2, Figure 3-3), there is

no statistically significant difference (p value = 0.4) between the two groups. Statistical

analysis was provided by Dr. Gary Stevens, University of Florida Biostatistics

Department.

 The values were attained using the Analysis for Linear Trend in Proportions.