variations in the material and geometric parameters. Fuzzy set analysis was employed to model the uncertainties in the response. Buckling loads of the thin walled stiffened panels are highly sensitive to geometric imperfections. Elseifl et al. (1999) applied a convex model to represent the worst-case geometric imperfection. The results obtained with this convex model were compared to the traditional probabilistic models used to account for uncertainties in imperfections. This chapter presents reliability-based designs of isogrid stiffened panels. The problem is to minimize the weight of the stiffened panel subj ect to a reliability constraint. The reliability-constraint is evaluated by Monte Carlo simulation, which requires a large number panel analyses. The PANDA2 software (Bushnell, 1987) is employed to analyze the stiffened panels. PANDA2 uses a combination of approximate physical models, exact closed form (finite-strip analysis) models and 1-D discrete branched shell analysis models to calculate pre-buckling, buckling and post-buckling responses with highly efficient analysis. PANDA2 also provides limited deterministic global optimization based on multiple starting points strategy. Under compressive loads, the load carrying capacity of stiffened panels is greatly affected by geometric imperfections due to fabrication. The effects of geometric imperfections are taken into account in PANDA2 software directly by modifying the effective radius of a cylindrical panel and indirectly by redistributing the pre-buckling stress resultants over the various segments of the panel. Various geometric imperfections, such as global, local, inter-ring, and general ovalization of cylindrical panels are considered, with a sophisticated methodology to identify the most detrimental imperfections. (Bushnell, 1996).