x and d are the random variable and design variable vectors, respectively. They recommended Latin Hypercube sampling as the statistical design of experiments. The number of response surface approximations constructed in optimization process is reduced substantially by introducing design variables into the response surface approximation formulation. The selection of RSA approach depends on the limit state function of the problem and target probability of failure. The global RSA approach is more efficient than local RSA, but it is limited to problems with relatively high probability or limit state function that can be well approximated by regression analysis based on simple basis functions. To avoid the extrapolation problems, RSA generally needs to be constructed around important region or MPP to avoid large errors in the results of MCS induced by fitting errors in RS. Therefore, an iterative RSA is desirable for general reliability analysis problem. Design response surface approximations (DRS) are fitted to probability of failure to filter out noise in MCS and facilitate optimization. Based on past experience, high-order DRS (such as quintic polynomials) are needed in order to obtain a reasonably accurate approximation of the probability of failure. Constructing highly accurate DRS is difficult because the probability of failure changes by several orders of magnitude over small distance in design space. Fitting to safety index /7=-0 (p), where p is the probability of failure and & is the cumulative distribution function of normal distribution, improves the accuracy of the DRS to a limited extent. The probabilistic sufficiency factor can be used to improve the accuracy of DRS approximation.