* Determining a mathematical model that best fits the data generated from the design points of DOE by performing statistical test of hypotheses of the model parameters(Khuri and Cornell 1996 and Myers et al. 2002) * Predicting response for given sets of experimental factors or variables by the constructed response surface approximation. Due to the close form nature of the approximation, RSA is particularly attractive for engineering problems that require a large number of computationally expensive analyses, such as structural optimization and reliability analysis. The accuracy of RSA is measured by error statistics such as the adjusted coefficient of multiple determination (R2adj), root mean square error predictor (RMSE), and coefficient of variation (COV =RMSE/Mean of Response). An R2adj close to one and a small COV close to zero usually indicate good accuracy. The RSAs in this dissertation were all constructed by JMP software (SAS Institute., 2000). The above error statistics are readily available from JMP after RSA construction. Khuri and Cornell (1996) presented a detailed discussion on response surface approximation. This chapter presents the response surface approach developed for reliability- based design optimization. Stochastic Response Surface (SRS) Approximation for Reliability Analysis Among the available methods to perform reliability analysis, moment-based methods (e.g., FORM/SORM) are not well suited for the composite structures in cryogenic environments because of the existence of multiple failure modes. Direct Monte Carlo simulation requires a relatively large number of analyses to calculate probability of failure, which is computationally expensive. Stochastic response surface approximation is employed here to solve the above problems. To apply RSA to a reliability analysis problem, the limit state function g(x) (usually the stress of displacement in the structures) is approximated by