The purpose of this study was to explore the relation- ship between psychosocial variables and the survival of elderly cancer patients when important biological, disease, and medical variables are controlled. The focus was on the relationship between psychosocial variables and survival and on the extent to which the variability in survival could be explained by a set of psychosocial variables. The contri- bution of concurrent physical conditions other than cancer to the patients' survival was also considered. The significance of this study is related to the methods that were used to identify and analyze the effects of several kinds of variables on cancer patient survival. Although research suggests that the survival of cancer patients may be related to psychosocial variables, many variables affect survival, including those related to the disease and treatment. For this reason, careful consideration must be given to the methods used to measure the effects of complicated psychosocial variables. The problems inherent in studying the effects of variables like the will to live and the willingness to fight the disease must be acknowledged and addressed. The appropriate interpretation of findings concerning the relationship between psychosocial variables and survival depends on how and to what extent these issues are addressed. This study was designed to clarify the relationship between