The general approach is to conduct a set of trials having standard experimental and treatment design, plot size, and number of replications throughout the region. A brief description of some of the more important choices to be made in designing these experiments follows. Experimental Designs A randomized complete block design is preferred, because of its simplicity and precision. Split-plot or Latin square designs are also possibilities, but they may be unnecessarily complex. A separate randomization should be carried out for each block of the trial at each site. In other words, a standard randomization should not be used for all sites. Number of Replications To provide an estimate of the experimental error from each site, replicates within sites are necessary. Three or four randomized blocks are recommended, although in extremely limited land situations two blocks per site could be used if compensated for by more sites. For highly variable conditions (such as plant disease control experiments), more than four replications may be required. Number of Treatments In order to keep the land area small and to limit the complexity of the trials from a management point of view, the number of treatments should be as small as possible and not exceed 15 to 20. As an example, a complete 33 factorial N-P-K rate trial would require 27 treatments, which would be too many. The number of treatments can be reduced by such techniques as confounding to generate incomplete factorials or using other appropriate treatment designs (double square, central composite, etc.).