DESCRIPTIONS INSTRUCTIONAL STAFF 1992-93 James, M.O.; Chair; Bergeron, R.; Perrin, J.; Prokai, L.; Rao, K.V.; Schulman, S.; Sloan, K.; Streiff, R. PHA 4352 Folk Medicine. F. Credits: 2; Prereq: PHA 4430 or permission of instruc- tor. Folk medicine in the use of herbal remedies and dietary changes in the prevention and treatment of disease. This course provides a basic understanding of the pharmaceutical, medical and social aspects of folk medicine as it is being practiced in the U.S. PHA 4413 Chromatographic Separations. F. Credits: 1; Prereq: PHA 3113C or permission from the instructor. Lecture and laboratory course for the study of meth- ods for the qualitative and quantitative determination of drugs in pharmaceutical products by chromoto- graphic methods. PHA 4430 Medicinal Chemistry 1-Natural Products. S. Credits: 4; Prereq: BCH 4024 and Pharmacy classifi- cation. Isolation, structure and pharmaceutical applications of natural products used as prescription and nonpre- scription drugs, with emphasis on structure/activity associations. PHA 4431 Medicinal Chemistry 2. F. Credits: 3; Prereq: Pharmacy classification. The relationship of physical and chemical factors to drug activity of inorganic and organic medicinal com- pounds. PHA 4432 Medicinal Chemistry 3. S. Credits: 3; Prereq: PHA 4431. This course emphasizes the relationship of physical and chemical factors to drug activity of inorganic and organic medicinal compounds. Structure/activity relationships, toxicity, and metabolism of medicinal compounds are examined. PHA 4906 Problems in Medicinal Chemistry. F, S. Credits: 1 to 2tt; Prereq: PHA 4430, an average of 2.75 in all courses taken and permission of the instructor. May be repeated with a change in course content up to a maximum of 6 credits. Library and/or laboratory research on assigned sub- jects. PHA 5657 Clerkship Research in Medicinal Chemistry. F, S, SS. Credits: 4; Prereq: Permission of the department. This course requires the student to participate in all phases of a research project. The student will be involved in designing and implementing the project as well as interpreting data and reporting the results of the research. GRADUATE COURSES Please refer to the Graduate Catalog for graduate course listings. INSTRUCTIONAL STAFF 1992-93 Derendorf, H., Chair; Bodor, N.; Brazeau, G.; Hammer, R.; Hochhaus, G.; Longer, M.; May, F.; Prokai, L.; Schwartz, M.; Tibbett, I. Pharmaceutics PHA 3110 Pharmaceutics I. F. Credits: 3; Prereq: Pharmacy classification. A review of essential mathematics, statistics, calculus and concentration expressions is given. An introduc- tion to basic thermodynamics leads to studies of acid- base equilibria, partitioning, solubility, colligative and surface properties. The chemical stability and kinetics of drug degradation are discussed. PHA 3111 Pharmaceutics II. S. Credits: 3; Prereq: Pharmacy classification. Theory and practice of pharmaceutical formulations. The formulation of conventional, advanced, and experimental dosage forms including sustained- release and controlled-release therapeutic systems. Novel concepts of controlled drug input and recent approaches to drug targeting are discussed. A short introduction to peptide and protein drug formulations is provided. PHA 3113C Pharmaceutical Analysis. F. Credits: 3; Prereq: Pharmacy classification. This lecture and laboratory course provides the understanding for basic principles and procedures employed in the qualitative and quantitative analysis of drugs in pharmaceutical products and biological fluids. Topics include sample preparation, volumetric methods, chromatography, potentiometry, spec- troscopy, enzymatic and immunological assay proce- dures. PHA 4103C Compounding and Parenterals. S. Credits: 3; Prereq: PHA 4120 and PH/PD or PHIPHA classification. Physical and chemical problems associated with the dispensing of prescribed medications, bioavailability, bio-equivalence and adjustment of dosage regimens. The laboratory will consist of applying the above the- oretical principles to the dispensing of prescriptions and the preparation of sterile products. PHA 4120 Pharmacokinetics-Biopharmaceutics. F. Credits: 4; Prereq: Pharmacy classification. An introduction to the study of the time course of drugs in the body with reference to their absorption, distribution, metabolism and elimination. Consideration is given to rate processes, the physio- chemical influences on ADME and formulation factors involved in drug delivery and availability. PHA 4123 Clinical Pharmacokinetics. F. Credits: 4; Prereq: PH/PD or PH/PHA classification or approval of instructor. Integration and application of pharmacokinetic princi- ples in the formulation of a rational dosage regimen, and in adjustment of existing regimens. Special emphasis is given to patient factors such as disease states and age, and drug product factors such as for- mulation and drug interactions. The course includes an introduction to the knowledge and skills required in the use of pharmacokinetic principles in the selec- tion and evaluation of drug therapy, and in individu- alization of dosage regimens for particular patients. PHA 4905 Problems in Pharmaceutics. F, S, SS. Credits: 1 to 2tt; Prereq: Pharmacy classification. May be repeated with a change in course content up to a maximum of 6 credits. Laboratory and/or literature investigations of prob- lems in pharmacy of current interest. PHA 4933 Selected Topics in Pharmacy. F, S, SS. Credits: 1 to 3; Prereq: Consent of instructor. PHA 5655 Clerkship Research in Pharmaceutics. F, S, SS. Credits: 4; Prereq: Permission of the department. This course requires the student to participate in all phases of a research project. The student will be involved in designing and implementing the project as well as interpreting data and reporting the results of the research. GRADUATE COURSES Please refer to the Graduate Catalog for graduate course listings. INSTRUCTIONAL STAFF 1992-93 Katovich, M., Chair; Dawson, R.; Elrod, K.; Finger, K.F.; Gause, G.; Keller-Wood, M.; Meldrum, M.; Millard, W.; Peris, J.; Simpkins, J. PHA 3500 Applied Human Anatomy and Physiology I. F. Credits: 4; Prereq: Pharmacy classification. Gross anatomy of the important organ systems of the human and mammalian are reviewed and discussed. PHA 3501 Applied Human Anatomy and Physiology II. S. Credits: 3; Prereq: PHA 3500. This is the second course in the sequence of PHA 3500 and 3501. PHA 3751 Microbiology. S Credits: 3; Prereq: Pharmacy classification. Basic principles of immunology and microbiology with a medical orientation. Lectures, laboratory demonstrations and discussions. PHA 4510 Pharmacology I. F. Credits: 3; Prereq: BCH 4024, PHA 3751, PHA 3500 and PHA 3501; Coreq: PHA 4120, PHA 4560, PHA 4430 or permission of the course coordinator. Principles of pharmacology based on conjoint discus- sion of normal and abnormal physiologic and bio- chemical mechanisms. Special emphasis on drug dis- tribution, metabolism, acid-base balance, digestive and excretory mechanisms, and endocrine pharmacol- ogy. PHA 4511 Pharmacology II. S. Credits: 4; Prereq: PHA 4510 or permission of the course coordinator. Continuation of PHA 4510 with special emphasis on nervous and cardiovascular function, and chemother- apy. PHA 4560 Pathophysiology. F. Credits: 4; Prereq: PHA 3500 and PHA 3501. Introduction to disease processes. PHA 4902 Problems in Pharmacodynamics. F, S, SS. Credits: I to 2tf; max: 6; Prereq: Pharmacy classifica- tion and approval of departmental chair. May be repeated with a change in course content up to a maximum of 6 credits. Laboratory and/or literature investigations of prob- lems in pharmacodynamics. PHA 5656 Clerkship Research in Pharmacodynamics. F, S, SS. Credits: 4; Prereq: Permission from the department. This course requires the student to participate in all phases of a research project. The student will be involved in designing and implementing the project as well as interpreting data and reporting the results of the research. GRADUATE COURSES Please refer to the Graduate Catalog for graduate course listings. tt Grading is on S-U basis only.