systems. Emphasis on compounds' mechanism of action and experimental techniques for evaluation of neurotoxicity. PHA 6508-Mammalian Physiology 1 (4) Prereq: background in the biological sciences or consent of instructor. Homeostatic regulation of the musculoskeletal, neural and endocrine systems with emphasis on integrative research approach. PHA 6509-Mammalian Physiology 11 (4) Prereq: PHA 6508 or consent of instructor. Homeostatic regulation of the respiratory, circulatory, renal, and gastrointestinal organ systems with empha- sis on integrative research approach. PHA 6521C-Research Techniques in Pharmacodynamics (2) Prereq: graduate standing. Discussions and laboratory practical experience with research techniques. PHA 6540-Neurochemical Foundation of Pharmacodynamics (3) Introduction to neurochemical mechanisms involved in drug action. Overview of neurotransmitter biochemistry along with receptor pharmacology. Emphasis on both methodological and theoretical aspects of neurotransmitter methobolism and func- tion. PHA 6541-Pharmacodynamics of Drugs of Abuse (3) Prereq: PHA 6540 or GMS 6500 or 6735 or consent of instructor. Readings, discussion, and lectures on recent advances in study of how drugs of abuse affect neurophysiology. Emphasis on theoreti- cal aspects of neurotransmission. PHA 7939-journal Colloguy in Pharmacodynamics (1; max: 8) Critical presentation and discussion of recent original articles. PHARMACOLOGY AND THERAPEUTICS College of Medicine GRADUATE FACULTY 1992-93 Chairman: S. P. Baker. Graduate Coordinator: L. C. Garg. Graduate Research Professors: H. M. Johnson;T. H. Maren. Professors: S. P. Baker; L. Belardinelli; M. Corbett; F. T. Crews; K. F. Finger; L. C. Garg; E. Goldberg;M.J. Greenberg; M. O. James; W. R. Kem; K. C. Leibman (Emeritus); A. H. Neims; K. T. Shiverick; D. N. Silverman; P. Stacpoole; C. Wilcox. Associate Professors: M. G. Humphreys-Beher; E. M. Meyer; W. J. Millard; T. F. Muther; T. C. Rowe; P. Scarpace. AssociateScientist:C. K. Tu. Assistant Professors: M. E. Knight; A. J. Mariotti. Assistant Scientists: S. E. Borst; W. F. Brechue. The Department of Pharmacology and Therapeutics offers a program leading to the degree of Doctor of Philoso- phy in the medical sciences with specialization in pharma- cology. The general focus research of the Department is mecha- nistic, at the cellular and molecular levels. Specific areas of research include receptor and membrane pharmacology; autonomic, renal, developmental, endocrine, gastrointesti- nal, and neuropharmacology; teratology; fluid secretion and carbonic anhydrase inhibition; cancer chemotherapy and carcinogenesis; physical chemistry of enzymes; opioid peptides; drug metabolism; and environment and marine toxicology. Applicants should present undergraduate course credits in chemistry; elementary physics and biology; and math- ematics through calculus. Otherwise well-qualified stu- dents with certain deficiencies in preparation will be al- lowed to make these up during the first year of graduate study. In addition to elementary and advanced study in pharmacology, candidateswill pursue courses in biochem- istry, physiology, and other medical sciences as determined by consultation with their advisory committees. PHARMACOLOGY AND THERAPEUTICS / 151 BMS 5473-Advanced Medical Pharmacology (4) GMS 6500--ntroduction to Pharmacology (6) Prereq: elemen- tary courses in biochemistry and physiology. Overview of the entire field of pharmacology as the study of the interactions between living systems and foreign chemicals. Intended to pre- pare majors for advanced courses orto familiarize nonmajors with the area. GMS 6520-Autonomic and Cellular Pharmacology (2) Prereq: GMS 6500. A biochemical approach to the actions of drugs on the autonomic nervous system, receptor coupling mechanisms, modu- lation of neurotransmitter release, and immune system pharma- cology. GMS 6530-Renal and Endocrine Pharmacology (2) Prereq: GMS 6500. Pharmacology and toxicology of hormones and renal drugs. GMS 6563-Molecular Pharmacology (3) Prereq: GMS 6500, CHM 3401. A biochemical approach to the actions of drugs, stressing analysis of drug-receptor interactions, structure-activity relationships, kinetics of distribution of drugs, and metabolism of foreign compounds. GMS 6590-Seminar in Pharmacology (1; max: 15) Prereq: GMS 6500. Research reports and discussions of current research litera- ture by graduate students, faculty, and invited lecturers. GMS 6735-Neuropharmacology (3) Prereq: background in biochemistry and basic neuroscience or consent of instructor. Identification, synthesis, metabolism, and pharmacology of neu- rotransmitters and their receptors, to include biogenic amines, neuropeptides, and other nervous system transmitters. GMS 7591-Research Methods in Pharmacology (1-3; max: 6) Readings, discussions, and practical experience with modern methods used in pharmacology. Chemical and biological meth- ods. GMS 7593-Topics in Pharmacology and Toxicology (1-3; max: 12) Seminars, informal conferences, or laboratory work on se- lected topics. PHARMACY HEALTH CARE ADMINISTRATION College of Pharmacy GRADUATE FACULTY 1992-93 Chairman: C. D. Hepler. Graduate Coordinator: R. Segal. Professors: D. B. Brushwood; C. D. Hepler. Associate Professors: D. H. Berardo; C. L. Kimberlin; L. D. Ried; R. Segal. Assistant Professors: E. E. Lipowski; P. L. Ranelli. Research in the Department emphasizes the sociobehav- ioral, administrative, legal, and economic aspects of drug therapy and pharmaceutical services, including assessment of safety, effectiveness, and efficiency aspects of patient- oriented pharmaceutical services. Graduate studies include core curricula encompassing the drug use process, statistics and research design, behav- ioral sciences, and economics. Electives and required courses draw from the resources of the entire University. They provide necessary concepts, knowledge, and skills for practical problem-solving and basic research. Graduates are prepared for leadership positions in academia, public service, and practice management related to drug therapy and pharmacy practice. Applicants with backgrounds in pharmacy, nursing, other health professions, or behavioral sciences are welcomed. Admission to the graduate program does not require a degree in pharmacy or another health profession although some familiarity with health care and health professions is recommended.