GMS 5391-Topics in Mechanisms of Disease (1-3; max: 3) Prereq: BMS 5603 or consent of instructor. Analysis and discus- sion of contemporary topics, including genetic predisposition to disease, autoaggression, autoimmunity, immunodeficiencies, al- tered cell growth, and cancer. Evaluation of most recently pub- lished literature. Seminars and discussions with invited speakers. GMS 6140-Principles of Immunology (3-5; max: 5) Biological and biochemical aspects of hosts resistance and immunity; the chemical and physiochemical properties of the proteins of im- mune reactions. GMS 6305-Pathobiology of Bone and Joint Disease (3) Prereq: consent of instructor. Disease mechanism and structural func- tional alterations of the skeletal system. GMS 6330-Tumor Biology (3) Prereq: cell biology, molecular biology, orconsentof instructor. Molecular pathologyof neoplasia; ocogenes and tumor suppressor genes; tumor progression and metastasis. Advanced topics format with emphasis on critical evaluation of experiments and grant writing. GMS 6331-Experimental Tumor Biology (2) Prereq: GMS 6330 or consent of instructor. Development of laboratory skills and techniques used in study of various phenomena in tumor biology. Students will work in direct association with members of the GMS 6630 teaching faculty. GMS 6332-Advanced Topics in Cancer Research (3) Prereq: GMS 6140, BMS 5603. Analysis and discussion of contemporary topics in tumor biology and molecular mechanisms ofoncogenesis to obtain a comprehensive understanding of the development of current concepts. Evaluation of the most recently published research literature. Seminars and discussions with invited speak- ers. GMS 6333-Mammalian Genetics and Inheritance of Disease Susceptibility (3) Prereq: BCH 6415 or GMS 6152 or consent of instructor. Basic principles of genetics in mammals including man. Inheritance of disease and disease susceptibility with de- tailed examples and relevance to current medical knowledge. GMS 6341-Immunopathology (2) Abnormalities and diseases having immunological bases are studied. GMS 6342L-Experimental Immunology (2) Prereq: consent of instructor; coreq: GMS 6140. Project oriented. Laboratory skills and techniques in immunobiology developed. Each studentworks in close association with a faculty member. GMS 6345-Pathobiology of Cellular Membranes (2) Prereq: MCB 6401. Discussion on structural and functional changes of membranes involved in disease states. GMS 6646-Experimental Pathology and Immunology: A Rota- tion (2-12; max: 16) Prereq: GMS 6140, BMS 5603, and consent of instructor. Individual investigative projects. Participation in all phases of experimental pathology and immunology. Laboratory training in methodology and data interpretation of basic research. Students specializing in experimental pathologyand immunology must spend three semesters on this rotation. GMS 6347-Advanced Methods in Immunology (2) Prereq: consent of instructor; coreq: GMS 6140. A laboratory course to gain practical experience with methods used in immunology research today. Cell separation and identification techniques, isolation and analysis of protein structure, electrophoretic and chromatographic isolation procedures, hybridoma production and monoclonal antibody screening procedures, and genetic engineering. GMS 6380-Special Subjects in Systemic Pathology (1-3; max: 3) Prereq: consent of instructor. Pathological processes affecting specific organs and organ systems. GMS 6381-Special Topics in Pathology (1-4; max: 12) Prereq: permission of department. Conferences and supervised labora- tory work. Topics selected to meet each student's needs. GMS 6382-Special Topics in Immunology (3; max: 6) Prereq: GMS 6140. Analysis and discussion of contemporary topics in immunology to obtain a comprehensive understanding of the development of current concepts. Evaluation of the most recently published research literature. Seminars and discussions with invited speakers. GMS 6390-Seminar in Pathology (1; max: 12) Required of graduate students in pathology; open to others by permission of PHARMACEUTICAL SCIENCES-GENERAL/149 the department. Current research literature and research reports by graduate students, pathology staff, and invited speakers. S/U. Clinical Chemistry GMS 6312-Clinical Chemistry and Toxicology (4) Chemical techniques employed in the diagnosis of disease; methods in toxicology. GMS 6313-Clinical Chemistry and Toxicology: A Rotation (2- 20; max: 20) Prereq: GMS 6312. Participation in all phases of practical clinical chemistry and toxicology. Chemical methodol- ogy, clinical interpretation, and significance of laboratory meas- urements used in diagnosing diseases. Individual investigative project in clinical chemistry and toxicology. Pathology graduate students specializing in clinical chemistry must spend three semesters on this rotation. S/U. GMS 6393-Seminar in Clinical Chemistry (1; max: 7) Prereq: consent of instructor; coreq: GMS 6312. Reports and discussions of current research and clinical literature presented by faculty, invited speakers, and graduate students. S/U. Clinical Immunology GMS 6349-Clinical Immunology: A Rotation (2-12; max: 12) Prereq: consent of instructor; coreq: GMS 6140. Individual inves- tigative projects. Laboratory training in the performance and interpretation of clinical immunology laboratory tests. Applica- tion of concepts of immunopathology and immunogenetics to the clinical laboratory management of immunologic problems. Stu- dents specializing in clinical immunology must spend three consecutive semesters in this rotation. Clinical Virology GMS 6348-Clinical Virology:A Rotation (2-12; max: 12) Prereq: consent of instructor. Participation in all phases of practical clinical virology. Laboratory training in methodology, clinical interpretation, and significance of clinical virology, with empha- sis on diagnostic procedures. Individual investigative projects. Students specializing in clinical virology must spend three con- secutive semesters on this rotation. PHARMACEUTICAL SCIENCES- GENERAL College of Pharmacy Dean & Graduate Coordinator: M. A. Schwartz. The College of Pharmacy offers the Doctor of Philosophy and the Master of Science in Pharmacy degrees in the pharmaceutical sciences, with specialization in medicinal chemistry, pharmacodynamics, and pharmacy which in- cludes pharmaceutics, pharmacy health care administra- tion, and hospital pharmacy administration (M.S.P. only). Master of Science in Pharmacy degree studies specializing in hospital pharmacy administration are supervised jointly by the Department of Pharmacy Health Care Administra- tion and the Department of Pharmacy Practice. The graduate faculty and courses offered are listed under department headings in this Catalog. The courses listed below consist of seminar, supervised teaching, and re- search for thesis or doctoral dissertation. These courses are offered in each of the departments except the Department of Pharmacy Practice. For specific information on courses in the Department of Medicinal Chemistry please see page 138. This department is within the College of Pharmacy. Students who wish to pursue graduate studies in the rfpartments of Medicinal Chemistry, Pharmaceutics,