148/ FIELDS OF INSTRUCTION research is conducted prior to admission to candidacy (GMS 7979) and for the doctoral dissertation (GMS 7980). Prerequisites for admission in addition to those of the Graduate School, include a broad base of courses in mathematics, physics, organic and analytic chemistry, ad- vanced biology, and statistical methods. Specific require- ments may be obtained from the Graduate Coordinator. GMS 6170-Immunology and Immunopathology of the Oral Cavity (2) Specific and nonspecific immune factors in saliva, with special emphasis on secretary IgA. Immunology and immunopa- thology of oral soft tissues. GMS 6171-Experimental Techniques in Light and Electron Microscopy (4) Aspects of light and electron microscopy that pertain to biological and medical research. Laboratory includes training in cell and tissue processing, sectioning, staining, light and electron microscopy and photography. GMS 6172-Molecular Biology and Pathology of the Periodon- tium (2) Coreq:GMS 6121, 6140. Ultrastructure and biochemical composition of periodontal tissues, the microbial interrelations with the organic and inorganic components of periodontal tissues, the biochemical dynamics of gingival inflammation, and wound healing and the metabolic processes responsible for the compo- sition and flow of the gingival crevicular fluid. GMS 6173-Stomatognathic System: Form and Function (2) Prereq: GMS 5630; coreq: BMS 6510. Anatomy and function of head and neck muscles, temporomandibular joints, and salivary glands. Normal and abnormal mastication, deglutition, speech, and oral sensorimotor measures. GMS 6174-Oral Microbial Systems (2) Coreq: GMS 6121, 6140. Major bacterial pathogens of the oral cavity: their morphol- ogy, physiology, genetics, and ecologic associations. Roles of key organisms in oral diseases (e.g., caries and periodontitis) stressed. GMS 6175-Introduction to Oral Biology (2) Survey of anatomy and function of the head and neck, oral histology and ultrastruc- ture, pathology of the periodontium, and oral immunology and microbiology. Recommended for beginning students. GMS 6176-Biology of Tooth Supporting Structures I (1) Coreq: BCH 6740 or consent of instructor. Organization, vasculature, and innervation of the periodontium; chemistry; biosynthesis, biophysics, and degradation of collagen; studies of other associ- ated, unique proteins. GMS 6177-Biology of Tooth Supporting Structures II (1) Prereq: GMS 6176; coreq: BCH 6206 or consent of instructor. Develop- ment and function of the periodontal ligament; organization, development, biophysics, and biochemistry of bone; calcification mechanisms and bone remodeling; effects of hormones and nutrients on bone. GMS 6178-Glycoproteins: Structure, Function, and Biosynthe- sis (3) Prereq: BCH 6740. Current findings on the structures of N- and O-linked oligosaccharides, biosynthetic enzymes, intracellu- lar trafficking, and biological functions. GMS 6193-Research Conference in Oral Biology (1; max: 8) Critical discussion and appraisal of current research within de- partment by students and faculty. S/U. GMS 7179-Journal Colloquy (1; max: 8) Required of graduate students in oral biology; open to others by permission of the department. Critical presentation and discussion of recentoriginal articles in the oral biology literature. PATHOLOGY AND LABORATORY MEDICINE College of Medicine GRADUATE FACULTY 1992-93 Chairman:N. Maclaren. Associate Chairman:R. L. Hackett. Graduate Coordinator: S. R. Khan. Graduate Research Professor: H. M. Johnson. Professors: R. C. Braylan; C. A. Crandall; W. H. Donnelly; R. L. Hackett; L. M. Hutt- Fletcher; P. A. Klein; N. K. Maclaren; S. J. Normann; A. B. Peck; W. J. Riley;J. C. Scornik; R. T. Smith; E. K. Wakeland; E. J. Wilkinson; J. C. Woodard. Associate Professors:C. D. Buergelt; B. P. Croker; K. J. Kao; S. R. Khan; K. H. Rand; W. E. Winter. AssistantProfessors:M. A. Atkinson; R. L. Bertholf; M. M. Goodenow; W. H. Kastern; M. T. McCormack; W. K. Potts; L. J. Smith. The Department of Pathology and Laboratory Medicine, College of Medicine, in association with the Departmentof Comparative and Experimental Pathology, College of Vet- erinary Medicine, offers a program leading to the Doctor of Philosophy degree in medical sciences, specializing in immunology and molecular pathology. Areas of research within this program include cellular and molecular immu- nology, immunogenetics, immunochemistry, immunopa- thology, immunology of infectious diseases, tumor biology and virology, membrane biochemistry, molecular biology, and comparative and nutritional pathology. The Department of Pathology and Laboratory Medicine also offers a program leading to the Master of Science degree in medical sciences, specializing in clinical chem- istry, clinical immunology, or clinical virology. The specialization in experimental pathology and immu- nology emphasizes basic research while concentrations in clinical chemistry, clinical immunology, and clinical virol- ogy emphasize laboratory training for management and supervision of clinical laboratories. Careers in pathology offer a diversity of opportunities: service in diagnostic laboratories, basic research in immunology, pathology or genetic engineering, and teaching. Graduate students entering the experimental pathology and immunology specialization should have adequate undergraduate training in chemistry, biology, physics, and mathematics, with special emphasis on physiological, de- velopmental, and cellular biology. Flexibility in the gradu- ate program permits the student's course curriculum to be arranged according to his/her specific interests and needs. Each student is required to have a minimum of six credits each of pathology, immunology, cell science, and bio- chemistry/microbial genetics prior to taking the Ph.D. qualifying examination. Immunology and Molecular Pathology BMS 5603-Genetic, Molecular, and Cellular Bases of Disease (3) Analysis of concepts underlying the pathologic development and consequences of disease with discussions of current research literature. Cell response to injury, genetic predisposition to disease, autoaggression, autoimmunity, immunodeficiency dis- eases, and altered cell growth and cancer. BMS 6203-Cell Membranes: Molecular Biology and Function (2) Prereq: MCB 3020 or equivalents and consent of instructor. Composition, molecular organization, and assembly of biological membranes in both eukaryotes and prokaryotes. Alternates with BCH 7515, spring semester. BMS 7920-Colloquium in Experimental Pathology and Immu- nology (1; max: 12) Required of graduate students in pathology; open to others by permission of the department. Critical presen- tation and discussion of recent original articles in the fields of pathology, immunology, and molecular biology. GMS 5304C-Mechanisms of Disease (1-3; max: 3) Multidisci- plinary approach to disease and its prevention, coordinating molecular, structural, and functional alterations with emphasis on inflammation and on microbial, toxicological, and ischemia injury.