140/ FIELDS OF INSTRUCTION The Department also participates in the interdisciplinary specialization in toxicology. For more information, seethe Interdisciplinary Graduate Studies section of this Catalog. PHA 5359-Cancer Chemotherapy (2) Prereq: BCH 4024. The chemotherapeutic agents which are currently in clinical use or under trial are classified according to their general mode action and are presented with their relevant chemical, pharmaceutical, and biological characteristics. PHA 5437-Medicinal Chemistry I: Natural Products (4) Isola- tion, structure, and pharmaceutical applications of natural prod- ucts used as prescription and nonprescription drugs, with empha- sis on structure-activity relationships. PHA 5438-Medicinal Chemistry II (3) Relationship of physical and chemical factors to drug activity of inorganic and organic medicinal compounds. PHA 5439-Medicinal Chemistry III (3) Relationship of physical and chemical factors to drug activity of inorganic and organic medicinal compounds. Examination of structure/activity relation- ships, toxicity, and metabolism of medicinal compounds. PHA 5475-Synthesis of Prodrugs (3) Prereq: introductory or- ganic chemistry, medicinal chemistry, pharmaceutics. An outline of synthetic and physical chemical approaches to solving drug delivery, bioavailability, activity, potency, toxicity, and accept- ability problems. PHA 6115-Equilibria, Complexations, and Interactions of Drugs (3) Models for drug interactions in solution. Physical chemistry characteristics of drugs and their complexes in pharmaceutical systems. PHA 6354-Natural Medicinal Products I (3) Chemistry of compounds derived from plants and animals. PHA 6354L-Natural Medicinal Products 1 (2) Accompanying laboratory course for PHA 6354. Isolation and identification of plant and animal products. PHA 6355-Natural Medicinal Products 11 (3) Prereq:PHA 6354. PHA 6355L-Natural Medicinal Products 11 (2) Accompanying laboratory course for PHA 6355. Isolation and identification of plant and animal products. PHA 6417-Pharmaceutical Analysis II (3) PHA 6425-Drug Metabolism and Toxicity (2) Prereq: introduc- tory organic chemistry, biochemistry. Enzymology and mecha- nisms of drug metabolism. Examples of where metabolism leads toxicity. r'HA 6445-Drug Design (3) Prereq: PHA 6470. Theoretical treatment of structure activity relationships and approaches to drug design. PHA 6470-Synthetic Medicinal Products I (2) The application of modern synthetic organic chemistry to the synthesis of medici- nals. PHA 6471L-Synthetic Medicinal Products (3) PHA 6905C Research Procedures in Medicinal Chemistry (1-4; max: 12) PHA 6934-Seminar in Medicinal Chemistry (1; max: 3) Weekly presentation and discussion of research reports based on college programs or literature. S/U option. MICROBIOLOGY AND CELL SCIENCE College of Agriculture GRADUATE FACULTY 1992-93 Chairman: E. M. Hoffmann. Graduate Coordinator: S. R. Farrah. Graduate Research Professors: H. M. Johnson; R. R. Schmidt. Professors: P. M. Achey; H. C. Aldrich; J. E. Gander; E. M. Hoffmann; D. H. Hubbell; L. 0. Ingram; R. A. Jensen; J. F. Preston, 111; K. T. Shanmugam; P. H. Smith (Emeritus). Associate Professors: F. C. Davis, Jr.; D. E. Duggan; S. R. Farrah; W. B. Gurley; E. P. Previc; S. G. Zam. Assistant Professor: S. E. Coleman. Graduate study is offered leadingto the Master of Science and Doctor of Philosophy degrees in microbiology and cell science, with emphasis in one or more of the disciplines of biochemistry, cell biology, and microbiology. Instruction and guidance are collaborative among faculty in the Col- leges of Agriculture, Liberal Arts and Sciences, and Medi- cine. Areas of research include anaerobic metabolism; bio- mass conversion; nitrogen fixation; membrane and cell wall chemistry and biochemistry; immunology; virology; microbial ecology; bacterial and phage genetics; DNA, RNA, and protein synthesis; molecular aspects of develop- ment of procaryotic and eucaryotic systems; cell ultrastruc- ture. Prerequisites for admission to graduate study, in addition to those of the Graduate School, are a broad educational background including mathematics, physics, and chemis- try through organic, analytical, and physical chemistry; basic courses in botany and zoology; and preferably at least one course in microbiology. An undergraduate major in physical or chemical science, engineering, or general biol- ogy is usually acceptable. Receipt of an advanced degree requires detailed knowledge in microbiology, biochemis- try, and chemistry; undergraduate deficiencies may neces- sitate additional course work priorto entry into the graduate program. In addition to the courses listed below, the following will be accepted for credits toward graduate degrees in micro- biology and cell science: BCH 6206,6415, and GMS 6152. MCB 5458-EnergyTransformation in Microorganisms (3) Prereq: CHM 3120. Energy transformations of dissimilatory and assimilatory processes in microorganisms with emphasis on regu- lation and energy cycles. Applications to microbial energy transformations to low energy technology. MCB 6127-The Literature of Microbiology (2) Prereq: eight credits of microbiology. Bibliographic method in searching the literature. Literature of specific areas of the discipline. MCB 6315-Recombinant DNA Techniques (2) Prereq: BCH 6415 and/or GMS 6152 and consent of instructor. Application of recombinant DNA techniques, agarose gel electrophoresis and hybridization for the in vitro construction, selection, and charac- terization of chimeric E. coli vector plasmids. MCB 6409-Microbial Cell Structure and Function (3) Prereq: BCH 6206, 6415. Review of current knowledge concerning structure, function, and biosynthesis of microbial cells. MCB 6415-Comparative Biochemistry and Physiology of An- aerobic Bacteria (2) Prereq: undergraduate biochemistry and microbiology and consent of instructor. Biochemical principles which govern energy flow through anaerobic food chains. Rumen discussed as a model system. Emphasis on selected microbial species and details of metabolism influencing, microbial interac- tion, nutrition, substrate dynamics, HB flow, methanogenesis. MCB 6416-Nitrogen Metabolism in Plants and Microorganisms (2) Prereq: consent of instructor. Biochemistry, molecular genet- ics, and regulation of inorganic nitrogen assimilation and other aspects of nitrogen metabolism unique to bacteria, fungi, yeasts, algae, and higher plants. Offered spring semester in even num- bered years. MCB 6435-Molecular Radiation Biology (2) Prereq: under- graduate courses in biology, chemistry, and physics, and consent of instructor. A survey of the effects of ionizing and nonionizing radiation, with emphasis on cellular and molecular mechanisms. MCB 6456-Transcriptional Regulation (2) Prereq: BCH6415 or BMS 6352C and consent of instructor. Mechanisms regulating specific transcription in procaryotes and eucaryotes examined at the DNA and enzyme level. MCB 6485-Advanced Techniques in Microbiology and Cell Science (2-4; max: 4) Prereq: consentof instructor. Application of advanced techniques to experimental research in biochemistry, cell biology, and microbiology.