MEDICINAL CHEMISTRY / 139 biology, immunology and medical microbiology, neuros- cience, oral biology, pathology, pharmacology and thera- peutics, and physiology. The Department of Biochemistry and Molecular Biology offers separate Ph.D and M.S. programs. Training in these scientific disciplines is planned to prepare the student for a career in research and teaching, rather than in clinical practice for which the Doctor of Medicine degree program is designed. The graduate faculty and the courses offered are listed under department headings in this Catalog. A minor is not required but may be chosen in another of the basic sciences listed below or elsewhere in the Catalog. All facilities of the College of Medicine are available to graduate students in this program. Though an undergraduate major in biological or physical science is desirable, concentration in math- ematics or engineering is an appropriate foundation for the Ph.D. in medical sciences. Satisfactory completion of a thesis based on research is a requirement for a graduate degree in the medical sciences (see College of Medicine Catalog). A new interdisciplinary graduate emphasis in cell struc- ture and function in health and disease is being offered. Students are provided with a strong interdisciplinary back- ground, emphasizing the application of morphological, molecular, biophysical, genetic, and immunological ap- proaches to basic problems relating to cell function. The interdisciplinary nature of the study provides a broad spectrum of research opportunities tailored to the specific needs of each student. Approximately 50 faculty members participate. Research areas represented include develop- mental biology, gametogenesis, intracellular targeting, mo- lecularorganization and function of organelles, cytoskeleton, signal transduction, action of hormones and neurotransmit- ters, energy metabolism and control, visual biochemistry, cellular and molecular immunology, biomembranes/mem- brane transport, molecular basis of disease, cancer biology, and mechanisms of viral infection. Future information may be found under Interdisciplinary Graduate Studies or from the coordinator, Dr. Carl Feldherr, Department of Anatomy and Cell Biology. The interdisciplinary study in toxicology is coordinated by the Center for Environmental and Human Toxicology and is concerned with the effect of chemicals on human and animal health. Center-affiliated faculty is composed of approximately 20 to 30 scientists and clinicians interested in elucidating the mechanism of chemical induced toxicity and is drawn from the Colleges of Medicine, Veterinary Medicine, Pharmacy, and Engineering, and the Institute of Food and Agricultural Sciences. The broadly based, inter- disciplinary expertise provided by this faculty is also used to address complex issues related to the protection of public health and the environment. Additional information may be obtained from one of the codirectors, Dr. Kathleen Shiverick, Box 100267, JHMHSC, or (904) 392-3545. A third interdisciplinary emphasis in vision sciences is available. The Department of Ophthalmology serves as the administrative and logistical center. However, mostfaculty members are from the basic science departments-Anatomy and Cell Biology, Biochemistry and Molecular Biology, Immunology and Medical Microbiology, Neuroscience, Pathology and Laboratory Medicine, and Pharmacology and Therapeutics. Current interests include study of the regulation of gene expression in the mammalian retina and lens, especially during fetal development, biochemistry of vision in vertebrates and invertebrates, biochemistry and neurobiology of wound healing and neural tissue regenera- tion, and molecular and cell biology of animal model of retinal degeneration. Further information may be obtained from the program director, Dr. William W. Hauswirth, Box 100266, JHMHSC, (904) 392-0679. In addition, the College of Medicine offers a Medical Scientist Training Program (combined M.D.-Ph.D. degree) to highly qualified students. Candidates for this five-to- seven year program must satisfy admission requirements of both the College of Medicine and the Graduate School. Applicants should specify the basic science department to which admission is sought; they will be admitted following independent approval bythe Medical Admissions Commit- tee, the department graduate selection committee, and a Medical ScientistTraining Program Board. Applications are coordinated through the Office of the Dean of the College of Medicine. Study and dissertation research in depart- ments other than basic science departments in the College of Medicine may be included in this program. GMS 6901-Seminar in Biology of Disease (1; max: 8) Current advances in etiology and treatment of disease. S/U. GMS 6905-Research in Medical Sciences (1-10; max: 10) Supervised research other than that for the thesis or dissertation in anatomy and cell biology, biochemistry and molecular biology, immunology and medical microbiology, neuroscience, oral biol- ogy, pathology and laboratory medicine, physiology, and phar- macology and therapeutics. GMS 6910-Supervised Research (1-5; max: 5) S/U. GMS 6940-Supervised Teaching (1-5; max: 5) S/U. GMS 6971--Research for Master's Thesis (1-15) S/U. GMS 7979-Advanced Research (1-9) Research for doctoral students before admission to candidacy. Designed for students with a master's degree in the field of study or for students who have been accepted for a doctoral program. Not open to students who have been admitted to candidacy. S/U. GMS 7980-Research for Doctoral Dissertation (1-15) S/U. MEDICINAL CHEMISTRY College of Pharmacy GRADUATE FACULTY 1992-93 Interim Chairman: M. O. James. Graduate Coordinator: R. J. Bergeron. Professors: R. J. Bergeron; M. O. James; J. H. Perrin; K. V. Rao; S. G. Schulman; R. Streiff. Associate Professor: K. B. Sloan. The College of Pharmacy offers the Doctor of Philosophy and the Master of Science in Pharmacy degrees in pharma- ceutical sciences with specialization in medicinal chemis- try. Specific areas include research in drug metabolism, prodrugs, soft drugs, natural product chemistry, enzyme- substrate binding mechanisms, design and synthesis of medicinal agents, multiple pulse NMR techniques, effects of high pressure on biological membranes, site specific delivery of drugs, target organ toxicity, metal chelate de- sign, drug analysis, and drug-protein interaction. The applicant should have an undergraduate degree in pharmacy, chemistry, biology, or premedical sciences. A background in calculus and physical and organic chemistry is required. In addition to graduate medicinal chemistry courses in the College of Pharmacy, graduate courses in chemistry and biochemistry are required for the program.