136 / FIELDS OF INSTRUCTION Schreier. Professors: S. H. Curry; J. H. Perrin; S. G. Schulman; M.A. Schwartz. Associate Professor: H. Derendorf. Assistant Professor: H. Schreier. The Department of Pharmaceutics offers the Doctor of Philosophy and Master of Science in Pharmacy in the pharmaceutical sciences. Pharmaceutics is the scientific endeavor concerned with the design, formulation, evalu- ation, and use of drug delivery systems. A foundation in physical chemistry, chemistry, mathematics, as well as in the life sciences, is necessary. Its domain extends from .studies of the physiochemical properties of drugs and related molecules to investigations of the mechanisms of physiological processes affecting drug delivery and thera- peutic effectiveness. The general focus of research in the department in- volves the study of the design and evaluation of the dosage form. The design involves physical chemical studies and development of analytical techniques involving spectros- copy and chromatography. Evaluation includes the de- velopment of sensitive analytical techniques for the drug in biological fluids and the subsequent biopharmaceuti- cal and clinical pharmacokinetic studies. PHA 5121-Clinical Pharmacokinetics<4) Integrating and apply- ing pharmacokinetic principles to formulate a rational dosage regimen considering various patient factors and drug product factors. PHA 5124-Biopharmaceutics (4) Time course of drugs in the body with reference to their absorption, distribution, metabo- lism, and elimination. Rate processes, the physiochemical influ- ences on absorption, distribution, metabolism, and elimination and formulation factors involved in drug delivery and availabil- ity.' PHA 6107C-Parenterals (3) Principles of preparation and sterili- zation. Properties of materials, stability and interactions. PHA6115-Equilibria, Complexations, and Interactions of Drugs (3) Models for dtug interactions in solution. Physical chemistry characteristics of drugs and their complexes in pharmaceutical systems. PHA 6116-Stability and Kinetics of Drugs (3) Kinetics, mecha- nisms, and prediction of stability in vitro transformations of drugs in solution and in dosage forms. PHA 6125-Pharmacokinetics and Biopharmaceutics (3) Com- partmental analysis with computers. PHA 6170C-Pharmaceutical Product Formulation (3) The ra- tionale and design of pharmaceutical dosage forms. PHA 6416-Pharmaceutical Analysis 1 (3) Theory and applica- tions of separation of drugs and breakdown products from dosage forms and biological media. PHA 6417-Pharmaceutical Analysis II (3) Absorption, fluores- cence, phosphorescence, and spectroanalysis of drugs and re- lated compounds. PHARMACODYNAMICS College of Pharmacy GRADUATE FACULTY 1989-90 Chairman: M. J. Katovich. Graduate Coordinator: W. J. Millard. Professors:K. F. Finger;J. W. Simpkins. Associate Professors: M. J. Katovich; W. Millard. Assistant Profes- sors: R. Dawson; M. Meldrum, M. Keller-Wood. The Departmentof Pharmacodynamics offers the Doctor of Philosophy and Master of Science in Pharmacy in the pharmaceutical sciences with specialization in pharmacy which includes pharmacodynamics. Pharmacodynamics is an integrated field of study involving pharmacology, physiology, and toxicology in a holistic approach to drug action in living systems. The department focuses on neuroendocrinology, cardiovascular pharmacology, and neuropharmacology with diverse research interests in aging, hypertension; reproduction, menopause, neuro- toxicity, and environmental physiology. An undergraduate degree in pharmacy, chemistry, biology or related sciences is required. In addition to graduate courses in pharmacy, courses are taken in phar- macology and biochemistry in the College of Medicine and in statistics in the College of Liberal Arts and Sciences. PHA 6508-Mammalian Physiology I (4) Prereq: background in the biological sciences or consent of instructor. Homeostatic regulation of the musculoskeletal, neural and circulatory systems with emphasis on integrative research approach. PHA 6509-Mammalian Physiology II (4) Prereq: PHA 6508 or consent of instructor. Homeostatic regulation of the respiratory,' endocrine, renal, and gastrointestinal organ systems with empha- sis on integrative research approach. PHARMACOLOGY AND THERAPEUTICS College of Medicine GRADUATE FACULTY 1989-90 Interim Chairman:S. P. Baker. Graduate Coordinator: L. C. Garg. Graduate Research Professors: H. M. Johnson; T. H. Maren. Professors:S. P. Baker; M. Corbett; K. F. Finger; L. C. Garg; E. Goldberg; M. J. Greenberg; W. R. Kem; K. C. Leibman (Emeritus); A. H. Neims; K. T. Shiverick; D. N. Silverman; C. Wilcox. Associate Professors:S. R. Childers; F. T. Crews; M. 0. James; E. M. Meyer; T. F. Muther; P. Scarpace; P. Stacpoole. Associate Research Scientist:C. K. Tu. Assistant Professors:M. E. Knight; T. C. Rowe. Assistant Research Scientist: S. E. Borst. The Department of Pharmacology and Therapeutics offers a program leading to the degree of Doctor of Philosophy in the medical sciences with specialization in pharmacology. The general focus research of the Department is mecha- nistic, at the cellular and molecular levels. Specific areas of research include receptor and membrane pharmacol- ogy; autonomic, renal, developmental, endocrine, gastro- intestinal, and neuropharmacology; teratology; fluid se- cretion and carbonic anhydrase inhibition; cancer che- motherapy and carcinogenesis; physical chemistry of en- zymes; opioid peptides, drug metabolism; and environ- ment and marine toxicology. Applicants should present undergraduate course cred- its in chemistry; elementary physics and biology; and mathematics through calculus. Otherwise well-qualified students with certain deficiencies in preparation will be allowed to make these up during the first year of graduate study. In addition to elementary and advanced study in pharmacology, candidates will pursue courses in bio- chemistry, physiology, and other medical sciences as determined by consultation with their advisory commit- tees. BMS 5465-Advanced Medical Pharmacology (4) BMS 6400-Introduction to Pharmacology (5) Prereq:elementary courses in biochemistry and physiology. Overview of the entire field of pharmacology as the study of the interactions between living systems and foreign chemicals. Intended to prepare majors for advanced courses or to familiarize nonmajors with the area. BMS 6402-Autonomic and Cellular Pharmacology (2) Prereq: BMS 6400. A biochemical approach to the actions of drugs on the autonomic nervous system, receptor coupling mechanisms, modulation of neurotransmitter release, and immune system pharmacology. BMS 6403-Renal and Endocrine Pharmacology (2) Prereq: BMS 6400. Pharmacology and toxicology of hormones and renal drugs.