126 / FIELDS OF INSTRUCTION' ods to the study of steady and unsteady multidimensional flows, including compressible and incompressible, laminar and turbu- lent, reacting and nonreacting, viscous and inviscid. EML 6715-Topics in Fluid Dynamics (3) Prereq: EML 4702. EML 6716-Advanced Fluid Dynamics (3) Prereq: EML 4702. Extends the previous fluid flow courses to include a wider range of subject material and provide a background for convection heat transfer courses. EML 6717-Thermodynamics of Fluid Flow I (3) Prereq: EML 4702 Compressible flow; emphasis on two-dimensional flow in internal flow systems. EML 6718-Thermodynamics of Fluid Flow II (3) Prereq: EML 6717. Continuation of EML 6717. Emphasis on axisymmetric, unsteady, and hypersonic flow. EML 6905-Individual Projects in Mechanical Engineering (1-3; max: 12) EML 6910-Supervised Research (1-3; max: 5) S/U. EML 6911-Mechanical Research (1-3; max: 6) Research projects in mechanical engineering. EML 6934-Special Topics in Mechanical Engineering (1-4; max: 9) EML 6935-Graduate Seminar (1) EML 6936-Nonthesis Project (1-4; max: 6) An in-depth project for graduate students not pursuing a thesis master's degree. S/U. EML 6940-Supervised Teaching (1-5; max: 5) S/U. EML 6971-Research for Master's Thesis (1-15) S/U. EML 6972-Research for Engineer's Thesis (1-15) S/U. EML 7979-Advanced Research (1-9) Research for doctoral stu- dents before admission to candidacy. Designed for students with a master's degree in the field of study or for students who have been accepted for a doctoral program. Not open to students who have been admitted to candidacy. S/U. EML 7980-Research for Doctoral Dissertation (1-15) S/U. MEDICAL SCIENCES-GENERAL College of Medicine The College of Medicine offers programs leading to the Doctor of Philosophy and Master of Science degrees in medical sciences, with specialization in anatomy and cell biology, immunology and medical microbiology, neuros- cience, oral biology, pathology, pharmacology and thera- peutics, physiology, and veterinary medicine. The De- partment of Biochemistry and Molecular Biology offers separate Ph.D and M.S. programs. Training in these scien- tific disciplines is planned to prepare the student for a career in research and teaching, rather than in clinical practice for which the Doctor of Medicine degree pro- gram is designed. The graduate faculty and the courses offered are listed under department headings in this Catalog. A minor is not required but may be chosen in another of the basic sciences listed below or elsewhere in the Catalog. All facilities of the College of Medicine are available to graduate students in this program. Though an under- graduate major in biological or physical science is desir- able, concentration in mathematics or engineering is an appropriate foundation for the Ph.D. in medical sciences. Satisfactory completion of a thesis based on research is a requirement for a graduate degree in the medical sciences (see College of Medicine Catalog). In addition, the College of Medicine offers a Medical Scientist Training Program (combined M.D.-Ph.D. de- gree) to highly qualified students. Candidates for this five- to-seven year program must satisfy admission require- ments of both the College of Medicine and the Graduate School.' Applicants should specify the basic science department to which admission is sought; they will be admitted following independent approval by the Medical Admissions Committee, the department graduate selec- tion committee, and a Medical Scientist Training Program Board. Applications are coordinated through the Office of the Dean of the College of Medicine. Study and disserta- tion research in departments other than basic science departments in the College of Medicine may be included in this program. GMS 6901-Seminar in Biology of Disease (1; max: 8) Current advances in etiology and treatment of disease. S/U. GMS 6905-Research in Medical Sciences (1-10; max: 10) Supervised research other than that for the thesis or dissertation in anatomy, biochemistry, immunology and medical microbiol- ogy, neuroscience, oral biology, pathology, physiology, phar- macology, and veterinarymedicine. GMS 6910-Supervised Research (1-5; max: 5) S/U. GMS 6940-Supervised Teaching (1-5; max: 5) S/U. GMS 6971-Research for Master's Thesis (1.15) S/U. GMS 7979-Advanced Research (1-9) Research for doctoral stu- dents before admission to candidacy. Designed for students with a master's degree in the field of study or for students who have been accepted for a doctoral program. Not open to students who have been admitted to candidacy. S/U. GMS 7980-Research for Doctoral Dissertation (1-15) S/U. MEDICINAL CHEMISTRY College of Pharmacy GRADUATE FACULTY 1989-90 Chairman: N. S. Bodor. Associate Chairman: R. H. Hammer. Graduate Research Professor: N. S. Bodor. Professors: R. 1. Bergeron; R. H. Hammer; K. V. Rao; R. Streiff. Associate Professors: M. 0. James; K. B. Sloan. The College of Pharmacy offers the Doctor of Philoso- phy and the Master of Science in Pharmacy degrees in pharmaceutical sciences with specialization in medici- nal chemistry. Specific areas include research in drug metabolism, prodrugs, soft drugs, natural product chemistry, enzyme- substrate binding mechanisms, design and synthesis of medicinal agents, multiple pulse NMR techniques, ef- fects of high pressure on biological membranes, site specific delivery of drugs, and metal chelate design. The applicant should have an undergraduate degree in pharmacy, chemistry, biology, or premedical sciences. A background in calculus and physical and organic chem- istry is required. In addition to graduate medicinal chemistry courses in the College of Pharmacy, graduate courses in chemistry and biochemistry are required for the program. PHA 5359-Cancer Chemotherapy (2) Prereq: BCH 4024. The chemotherapeutic agents which are currently in clinical use or under trial are classified according to their general mode action and are presented with their relevant chemical, pharmaceutical, and biological characteristics. PHA 5475-Synthesis of Prodrugs (3) Prereq: introductory or- ganic chemistry, medicinal chemistry, pharmaceutics. An out- line of synthetic and physical chemical approaches to solving drug delivery, bioavailability, activity, potency, toxicity, and acceptability problems. PHA 6354-Natural Medicinal Products I (3) Chemistry of compounds derived from plants and animals. PHA 6354L-Natural Medicinal Products I (2) Accompanying laboratory course for PHA 6354. Isolation and identification of plant and animal products. PHA 6355-Natural Medicinal Products II (3) Prereq: PHA 6354. PHA 6355L-Natural Medicinal Products II (2) Accompanying laboratory course for PHA 6355. Isolation and identification of plant and animal products. PHA 6425-Drug Metabolism and Toxicity (2) PHA 6445-Drug Design (3) Prereq: PHA 6470. Theoretical treatment of structure activity relationships and approaches to drug design. PHA 6470-Synthetic Medicinal Products 1 (2) The application of modern synthetic organic chemistry to the synthesis of medici- nals. PHA 6470L-Synthetic Medicinal Products (3) Accompanying laboratory course for PHA 6470. Synthesis of organic medicinal compounds.