124 / FIELDS OF INSTRUCTION morphogenesis, pattern formation, and oncogenesis. BMS 6314-Principles of Immunology (3-5; max: 5) Biologi- cal and biochemical aspects of hosts resistance and im- munity; the chemical and physiochemical properties of the proteins of immune reactions. BMS 6601-Special Subjects in Systemic Pathology (1-3; max: 3) Prereq: consent of staff. Pathological processes affec- ting specific organs and organ systems. BMS 6603C-General Pathobiology and Laboratory (4) Pathologic aspects of immunological phenomena, sponta- neous disease and host mechanisms in response to injury or microbial and viral diseases. BMS 6607C-Pathobiology of Bone and joint Disease (3) Prereq: consent of instructor. Disease mechanism and struc- tural functional alterations of the skeletal system. BMS.6620-Seminar in Pathology (1) Required of graduate students in pathology; open to others by permission of the Department. Current research literature and research reports by graduate students, pathology staff, and invited speakers. S/U. BMS 6621-Special Topics in Pathology (1-4; max: 12) Pre- req: permission of Department. Conferences and supervised laboratory work. Topics selected to meet each student's needs: BMS 6622-Special Topics in Immunology (3; max: 6) Prereq: BMS 6314. Analysis and discussion of contemporary topics in immunology to obtain a comprehensive understanding of the development of current concepts. Evaluation of the most re- cently published research literature. Seminars and discus- sions with invited speakers. BMS 6630-Tumor Biology (3) Pathobiology, biochemistry, and molecular biology of neoplasia; viral and chemical carcinogenesis; immunology and therapy of cancer in man and animals. BMS 6631-Experimental Tumor Biology (2) Prereq: BMS 6630 or consent of instructor. Development of laboratory skills and techniques used in study of various phenomena in tumor biology. Students will work in direct association with members of the BMS 6630 teaching faculty. BMS 6641-Immunopathology (2) Abnormalities and dis- eases having immunological bases are studied. BMS 6642L-Experimental Immunology (2) Prereq: consent of instructor. Coreq: BMS 6314. Project oriented. Laboratory skills and techniques in immunobiology developed. Each student works in close'association with a faculty member. BMS 6645-Pathobiology of Cellular Membranes (2) Prereq: MCB'6401 Discussion on structural and functional changes of membranes involved in disease states. BMS 6646C-Experimental Pathology and Immunology: A Rotation (2-12; max: 16) Prereq: BMS 6314, 6603 and consent of instructor. Individual investigative projects. Participation in all phases of experimental pathology and immunology. Laboratory training in methodology and data interpretation of basic research. Students specializing in experimental pa- thology and immunology must spend three semesters on this rotation. BMS 6647L-Advanced Methods in Immunology (2) Prereq: consent of instructor. Coreq: BMS 6314. A laboratory course to gain practical experience with methods used in im- munology research today. Cell separation and identification techniques, isolation and analysis of protein structure, elec- trophoretic and chromatographic isolation procedures, hybridoma production and monoclonal antibody screening procedures, and genetic engineering. BMS 7920-Colloquium in Experimental Pathology and Im- munology (1) Required of graduate students in pathology; open to others by permission of the Department. Critical presentation and discussion of recent original articles in the fields of pathology, immunology, and molecular biology. S/U. Clinical Chemistry BMS 6612-Clinical Chemistry and Toxicology (4) Chemical techniques employed in the diagnosis of disease; methods in toxicology. BMS 6613--Clinical Chemistry and Toxicology: A Rotation (2-20; max: 20) Prereq: BMS 6612. Participation in all phases of practical clinical chemistry and toxicology. Chemical methodology, clinical interpretation and significance of lab- oratory measurements used in diagnosing diseases. Individ- ual investigative project in clinical chemistry and toxicology. Pathology graduate students specializing in clinical chemis- try must spend three semesters on this rotation. BMS 6623-Seminars in Clinical Chemistry (1) Prereq: con- sent of instructor. Required of graduate students,in clinical chemistry; open to others by permission of staff. Reports and discussions of current research and clinical literature pres- ented by clinical chemistry staff, invited speakers and gradu- ate students. BMS 7660-Medical Information Systems (2) Systems analy- sis techniques, both theoretical and practical, applied to the medical database. Communications within health care de- livery systems studied. Clinical Immunology BMS 6617C-Clinical Immunology: A Rotation (2-12; max: 12) Prereq: consent of instructor. Coreq: BMS 6314. Individ- ual investigative projects. Laboratory training in the per- formance and interpretation of clinical immunology labora- tory tests. Application of concepts of immunopathology and immunogenetics to the clinical laboratory management of immunologic problems. Students specializing in clinical im- munology must spend three consecutive semesters in this rotation. Clinical Virology BMS 6618C-Clinical Virology: A.Rotation (2-12; max: 12) Prereq: consent of instructor. Participation in all phases of practical clinical virology. Laboratory training in method- ology, clinical interpretation and significance of clinical vir- ology, with emphasis on diagnostic procedures. Individual investigative projects. Students specializing in clinical vir- ology must spend three consecutive semesters on this rota- tion. PHARMACOLOGY AND THERAPEUTICS College of Medicine GRADUATE FACULTY 1984-85 Chairman: A. H. Neims. Graduate Coordinator: S. P. Baker. Graduate Research Professor: T. H. Maren. Pro- fessors: M. Corbett; K. F. Finger; M. J. Greenberg; K. C. Leibman; A. H. Neims; D. N. Silverman. Associate Pro- fessors: S. P. Baker; j. U. Bell; L. C. Garg; W. R. Ker; T. F. Muther; W. E. Ross; K. T. Shiverick. Assistant Pro- fessors: S. R. Childers; F. T. Crews; I. Donovan; M. O. James; E. M. Meyer; P. Stacpoole. The Department of Pharmacology and Thera- peutics offers a program leading to the degree of Doc- tor of Philosophy in the medical sciences with special- ization in pharmacology. The general research focus of the Department is mechanistic, at the cellular and molecular levels. Spe- cific areas of research include receptor and mem- brane pharmacology; autonomic, renal, develop- mental, endocrine, gastrointestinal, and neu- ropharmacology; teratology; fluid secretion and carbonic anhydrase inhibition; cancer chemotherapy and carcinogenesis; physical chemistry of enzymes; opioid peptides, drug metabolism; and environment and marine toxicology. Applicants should present undergraduate course credits in chemistry; elementary physics and biology; and mathematics through calculus. Otherwise well- qualified students with certain deficiencies in prepa- ration will be allowed to make these up during the first year of graduate study. In.addition to elementary and advanced study in pharmacology, candidates will