116 / FIELDS OF INSTRUCTION The College of Pharmacy offers Master of Science in Pharmacy and Doctor of Philosophy degrees in phar- maceutical sciences with specialization in medicinal chemistry. Specific areas include research in drug metabolism, prodrugs, soft drugs, natural product chemistry, enzyme-substrate binding mechanisms, design and synthesis of medicinal agents, multiple pulse NMR techniques, effects of high pressure on biological sys- tems, delivery of drugs across biological membranes, site specific delivery of drugs, and metal chelate de- sign. The applicant should have an undergraduate de- gree in pharmacy, chemistry, biology, or premedical sciences. A background in calculus and physical and organic chemistry is required. PHA 6354-Natural Medicinal Products I (3) Chemistry of compounds derived from plants and animals. PHA 6355-Natural Medicinal Products It (3) Prereq: PHA 6354. PHA 6356-Natural Medicinal Products III (2) Prereq: PHA 6355. PHA 6357L-Natural Medicinal Products I (2) Accompany- ing laboratory course for PHA 6354. Isolation and identifica- tion of plant and animal products. PHA 6358L-Natural Medicinal Products II (2) Accompany- ing laboratory course for PHA 6355. Isolation and identifica- tion of plant and animal products. PHA 6445-Drug Design (3) Prereq: PHA 6470. Theoretical treatment of structure activity relationships and approaches to drug design. PHA 6470-Synthetic Medicinal Products I (2) The applica- tion of modern synthetic organic chemistry to the synthesis of medicinals. PHA 6471-Synthesis and Modification of Drugs (2) PHA 6473L-Synthetic Medicinal Products II (2) Accompa- nying laboratory course for PHA 6471. Synthesis of organic medicinal compounds. PHA 6474-Drug Metabolism and Toxicity (2) PHA 6905-Research Procedures in Medicinal Chemistry (1-4) Prereq: departmental consent. Laboratory research, ad- vanced discussion, and reading. Research problems of in- terest to the student and his program. PHA 6910-Supervised Research (1-5; max: 5) S/U. PHA 6934-Seminar in Medicinal Chemistry (1) Weekly presentation and discussion of research reports based on college programs or literature. S/U option. PHA 6938-Research Seminar (1) Seminar required of gradu- ate students in the College of Pharmacy. S/U option. PHA 6940-Supervised Teaching (1-5; max: 5) S/U. PHA 6971-Research for Master's Thesis (1-15) S/U. PHA 7979-Advanced Research (1-9) Research for doctoral students before admission to candidacy. Designed for stu- dents with a master's degree in the field of study or for stu- dents who have been accepted for a doctoral program. Not open to students who have been admitted to candidacy. S/U. PHA 7980-Research for Doctoral Dissertation (1-15) S/U. MICROBIOLOGY AND CELL SCIENCE College of Agriculture GRADUATE FACULTY 1984-85 Chairman: J. M. Gander. Graduate Coordinator: P. M. Achey. Graduate Research Professor: R. R. Schmidt. Professors: P. M. Achey; H. C. Aldrich; A. S. Bleiweis; j. W. Brookbank; G. E. Gifford; J. H. Gregg; E. M. Hoff- mann; D. H. Hubbell; L. 0. Ingram; j. F. Preston, III; P. H. Smith. Associate Professors: F. C. Davis, Jr.; D. E. Duggan; S. R. Farrah; E. P. Previc; K. T. Shanmugam; S. G. Zam. Assistant Professors: S. E. Coleman; W. B. Gurley. Graduate study is offered leading to the Master of Science and Doctor of Philosophy degrees in micro- biology and cell science, with emphasis in one or more of the disciplines of biochemistry, cell biology, and microbiology. Instruction and guidance are col- laborative among faculty in the Colleges of Agricul- ture, Liberal Arts and Sciences, and Medicine. Areas of research include anaerobic metabolism; biomass conversion and low energy technology; ni- trogen fixation; membrane and cell wall chemistry and biochemistry; immunology; virology; microbial ecology; bacterial and phage genetics; DNA, RNA, and protein synthesis; molecular aspects of develop- ment of procaryotic and eucaryotic systems; cell ul- trastructure. Prerequisites for admission to graduate study, in addition to those of the Graduate School, are a broad educational background including mathematics, physics, and chemistry through organic, analytical, and physical chemistry; basic courses in botany and zoology; and preferably at least one course in micro- biology. An undergraduate major in physical or chem- ical science, engineering, or general biology is usually acceptable. Receipt of an advanced degree requires detailed knowledge in microbiology, biochemistry, and chemistry; undergraduate deficiencies may ne- cessitate additional course work prior to entry into the graduate program. In addition to the courses listed below, the follow- ing will be accepted for credits toward graduate de- grees in microbiology and cell science: BCH 6065, 6206, 6415, and BMS 6352. MCB 5458-Energy Transformation in Microorganisms (3) Prereq: CHM 3120, BCH 4313. Energy transformationsof dis- similatory and assimilatory processes in microorganisms with emphasis on regulation and energy cycles. Application of microbial energy transformations to low energy technology. MCB 6315L-Recombinant DNA Techniques (2) Prereq: BCH 6415 and/or BMS 6352 and consent of instructor. Application of recombinant DNA techniques, agarose gel elec- trophoresis and hybridization for the in vitro construction, selection, and characterization of chimeric E. coli vector plasmids. MCB 6316-Plasmids, Transposons, and Recombinant DNA Technology (2) Prereq: BCH 6415 and/or BMS 6352 and con- sent of instructor. Background and current state of knowl- edge of plasmids, select bacteriophage, insertion sequences, transposons, mobile genetic elements of eucaryotes, and re- combinant DNA methods. MCB 6406-Bacterial Cell Surfaces (2) Prereq: advanced un- dergraduate courses in microbiology and biochemistry and consent of instructor. A comprehensive review of current knowledge concerning structure, function, and biosynthesis of procaryotic cell walls, with emphasis on the role of the. cell surface on adhesion in relation to colonization and ge- netic recombination. MCB 6415-Comparative Biochemistry and Physiology of Anaerobic Bacteria (2) Prereq: undergraduate biochemistry and microbiology and consent of instructor. Biochemical principles which govern energy flow through anaerobic food chains. Rumen discussed as a model system. Emphasis on selected microbial species and details of metabolism in- fluencing microbial interaction, nutrition, substrate dynam- ics, H flow, methanogenesis. MCB 6416-Nitrogen Fixation and Inorganic Nitrogen Me- tabolism (2) Prereq: consent of instructor. Coreq: BCH 6206 and/or BCH 6415. Biochemistry, physiology, genetics and regulation of nitrogen fixation and enzymes of ammonia and nitrate assimilation. MCB 6435-Molecular Radiation Biology (2) Prereq: under- graduate courses in.biology, chemistry, and physics, and consent of instructor. A survey of the effects of ionizing and non-ionizing radiation, with emphasis on cellular and molecular mechanisms. MCB 6455-Temporal Gene Expression in Cellular Develop-