emissions, and satellites. Emphasis is on Jupiter. AST 7279-Close Binary Stars (2) Prereq: AST 6274. Role of close binaries in stellar evolution. Nonperiodic phenomena, mass loss and exchange, novae and nova-like variables, pe- riod changes. AST 7939-Special Topics (2; max: 12) Assigned reading, pro- grams, seminar, or lecture series in a new field of advanced astronomy. AST 7979-Advanced Research (1-9) Research for doctoral students before admission to candidacy. Designed for stu- dents with a master's degree in the field of study or for stu- dents who have been accepted for a doctoral program. Not open to students who have been admitted to candidacy. S/U. AST 7980-Research for Doctoral Dissertation (1-15) S/U. PHS 6606-Special and General Relativity (4) Prereq: PHY 6246, tersor analysis, invariance. Einstein's special and gen- eral theories of relativity; relativistic cosmology. BIOCHEMISTRY AND MOLECULAR BIOLOGY College of Medicine GRADUATE FACULTY 1984-85 Chairman: D. L. Purich. Graduate Coordinator: P. J. Laipis. Professors: C. M. Allen, Jr.; R. P. Boyce; P. W. Chun; A. F. Esser; W. R. Fisher; M. Fried; R. J. Mans; T. W. O'Brien; D. L. Purich; R. M. Roberts; G. S. Stein; A. R. Stevens; M. Young. Associate Professors: R. D. Brown, Jr.; R. J. Cohen; B. M. Dunn; M. S. Kappy; P. J. Laipis. Assistant Professors: K. J. Angelides; V. Chau; M. S. Kilberg; P. M. McGuire. The Department of Biochemistry and Molecular .Biology offers the Master of Science and Doctor of Philosophy degrees in biochemistry with special- ization in physical biochemistry, molecular biology, cell biology, and medical biochemistry. Specific areas of study include structure and func- tion of cellular and nuclear membranes in mam- malian cells; transport of molecules into the cell; regu- lation of cell division and gene expression; assembly and regulation of the cytoskeleton; biochemistry of differentiation; biochemical genetics; molecular biology of nucleic acids; replication and repair in bac- terial and eukaryotic cells; biosynthesis and structure of nucleic acids, proteins, polysaccharides, lipids, lipdproteins; sensory biochemistry; isoprenoid me- tabolism; physical biochemistry of nucleic acids and proteins; mechanism of enzyme action; and molecular evolution. New graduate students should have adequate train- ing in general, organic, quantitative, and physical chemistry as well as in physics, biology, and calculus. Minor deficiencies may be made up immediately after entering Graduate School. Doctoral candidates are required to take several biochemistry courses which include BCH 6065, 6156, 6206, 6415, 6876 and 6936. Depending upon interests and background of the student, additional courses are recommended from the following list: BCH 6296, 6746, 7077 and 7257. The curriculum for doctoral can- didates may also include advanced chemistry, physi- ology, microbiology, and genetics courses. BCH 6065-Advanced Physical Biochemistry (3) Prereq: gen- eral biochemistry and physical chemistry or consent of in- structor. Physical chemistry of biological molecules and the techniques for their study. Constitutes one of the three core biochemistry courses. BCH 6156C-Research Methods in Biochemistry (1-4; max: 8) Coreq: BCH 6065, 6206, 6475. Only by special arrange- ment. Biochemical research in which the student refines re- BIOCHEMISTRY AND MOLECULAR BIOLOGY / 59 search techniques in physical biochemistry, intermediary metabolism, molecular biology, and cell biology under su- pervision of a staff member. S/U. BCH 6206-Advanced Metabolism (3) Prereq: general biochemistry or consent of instructor. The reactions of in- termediary metabolism with emphasis upon their integra- tions, mechanism, and control. Constitutes one of the three core biochemistry courses. BCH 6296-Advanced Topics in Metabolic Control (1) Pre- req: BCH 6065, 6206, 6415, or consent of instructor. Study of the thermodynamic, allosteric, hormonal, and genetic con- trol of metabolic reactions. BCH 6415--Advanced Molecular and Cell Biology (3) Prereq: general biochemistry or consent of instructor. An advanced course in the molecular biology of pro- and eukaryotes. Top- ics will include DNA replication, chromosome organization, RNA and protein synthesis, and molecular aspects of gene regulation. Constitutes one of the three core biochemistry courses. BCH 6746-Advanced Topics in Physical Biochemistry (1) Prereq: BCH 6065, 6206, 6415, or consent of instructor. Study of physical chemistry of proteins, nucleic acids, lipids, enzymes, as well as their modes of interaction. BCH 6876-Recent Advances in Biochemistry (1) Prereq: BCH 6065 or equivalent. Areas of biochemistry and molecular biology, selected by the faculty, discussed critically and in depth. Emphasis on current controversy and theory, data interpretations, and scientific writing. Classes held informally in small groups during each semester, in- volving all biochemistry faculty on a rotating basis. S/U. BCH 6910-Supervised Research (1-5; max: 5) S/U. BCH 6936-Biochemistry Seminar (1) Required of graduate students in biochemistry; open to others by special arrange- ment. Research reports and discussions of current research literature given by the departmental staff, invited speakers, and graduate students. S/U. BCH 6940-Supervised Teaching (1-5; max: 5) S/U. BCH 6971-Research for Master's Thesis (1-15) S/U. BCH 7077-Advanced Topics in Molecular Biology (1) Pre- req: BCH 6065, 6206, 6415, or consent of instructor. The bio- chemical basis of molecular biology and genetics with em- phasis on the mode of control surrounding the replication and expression of the pro- and eukaryotic genome. BCH 7257-Advanced Topics in Cell Biology (1) Prereq: BCH 6415 or equivalent. Biochemistry of selected cell organelles with emphasis on compartmentation and integrated cellular function. BCH 7515-Enzyme Kinetics and Mechanisms (2) Prereq: ad- vanced general course in biochemistry such as BCH 6056, 6206, or consent of instructor. The study of enzyme reaction mechanisms using kinetics, spectroscopy, protein crystallo- graphy and new emerging techniques. Alternates with BMS 6203, spring semester. BCH 7627-Biochemistry of Disease (2) Prereq: general courses in biochemistry and consent of instructor. The molecular basis of human pathobiology. Includes a review of some of the basic biochemical mechanisms underlying selected disease states. BCH 7979-Advanced Research (1-9) Research for doctoral students before admission to candidacy. Designed -for stu- dents with a master's degree in the field of study or for stu- dents who have been accepted for a doctoral program. Not open to students'who have been admitted to candidacy. S/U. BCH 7980-Research for Doctoral Dissertation (1-15) S/U. BMS 5180--Cell and Tissue Biology (4) Prereq: cell biology course and consent of instructor. Cell specializations and in- teractions that account for the organization and functions of the basic tissues (epithelium, connective tissue, muscle, and nerve). BMS 6203-Molecular Biology and Function of Cell Mem- branes (2) Prereq: BCH 4203, 4313 and MCB 3020 or equiva- lents and consent of instructor. Composition, molecular or- ganization, and assembly of biological membranes in both eukaryotes and prokaryotes. Alternates with BCH 7515, spring semester.