116 / FIELDS OF INSTRUCTION Field experience in clinical, community, educational, and ad- ministrative settings approved by the department. OTH 6905-Individual Work (1-10) Prereq: OTH 6539, OTH 6780. Project related to teaching, research, administration, or clinical practice. PATHOLOGY College of Medicine GRADUATE FACULTY 1982-83 Chairman: R. T. Smith. Associate Chairman: R. L. Hackett. Graduate Coordinator: A. B. Peck. Professors: R. Braylan; W. F. Enneking; A. Esser; R. R. Grams; R. L. Hackett; C. I. Hood; N. Maclaren; C. Moscovici; S. J. Normann; S. W. Russell; R. T. Smith; H. Stanley; J. C. Woodard. Associate Professors: H. H. Baer; C. D. Buergelt; C. A Crandall; W. H. Donnelly; P. A. Klein; K. H. Rand; J. C. Scornik; P. O.Teague. Assistant Pro- fessors: H. Burchardt; M. B. Calderwood; A. K. Kimura; A. B. Peck; A. C. Smith; E. K. Wakeland. The Department of Pathology, College of Medicine, in association with the Department of Comparative and Experimental Pathology, College of Veterinary Medicine, offers a program leading to the Doctor of Philosophy degree in medical sciences, specializing in experimental pathology and immunology. Areas of research within this program include cellular and molecular immunology, immunogenetics, immunochemistry, immunopathology, immunology of infectious diseases, tumor biology and virology, membrane biochemistry, molecular biology and comparative and nutritional pathology. The Department of Pathology also offers a program leading to the Master of Science degree in medical sciences, specializing in clinical chemistry, clinical im- munology, or clinical virology. The program in experimental pathology and immunol- ogy emphasizes basic research while programs in clini- cal chemistry, clinical immunology, and clinical virology emphasize laboratory training for management and super- vision of clinical laboratories. Careers in pathology offer a diversity of opportunities: service in diagnostic labora- tories, basic research in immunology, pathology or genetic engineering, and teaching. Graduate students entering the experimental pathology and immunology program should have adequate undergraduate training in chemistry, biology, physics and mathematics, with special emphasis on physiological, developmental and cellular biology. Flexibility in the graduate program permits the student's course curricu- lum to be arranged according to his/her specific interests and needs. Each student is required to have a minimum of six credits each of pathology, immunology, cell science and biochemistry/microbial genetics prior to taking the Ph.D. qualifying examination. Experimental Pathology and Immunology BMS 5181-Cell Differentiation and Morphogenesis (4) Prereq: comprehensive courses in developmental biology (or embryol- ogy), cell biology and biochemistry. Coreq: molecular biology or consent of instructor. Examination of evidence for current models of cell differentiation, proliferation, shape change and motility, especially as the models relate to morphogenesis, pat- tern formation, and oncogenesis. BMS 6314-Principles of Immunology (5) Biological and biochemical aspects of hosts resistance and immunity; the chemical and physiochemical properties of the proteins of immune reactions. BMS 6601-Special Subjects in Systemic Pathology (1-3; max: 3) Prereq: consent of staff. Pathological processes affecting specific organs and organ systems. BMS 6603C-General Pathobiology and Laboratory (4) Pathologic aspects of immunological phenomena, spontaneous disease and host mechanisms in response to injury or microbial and viral diseases. BMS 6607C-Pathobiology of Bone and joint Disease (3) Prereq: consent of instructor. Disease mechanism and structural functional alterations of the skeletal system. BMS 6620-Seminar in Pathology (1) Required of graduate students in pathology; open to others by permission of the department. Current research literature and research reports by graduate students, pathology staff, and invited speakers. BMS 6621-Special Topics in Pathology (1-4; max: 12) Prereq: permission of department. Conferences and supervised laboratory work. Topics selected to meet each student's needs. BMS 6622-Special Topics in Immunology (3) Prereq: BMS 6314. Analysis and discussion of contemporary topics in im- munology to obtain a comprehensive understanding of the development of current concepts. Evaluation of the most recently published research literature. Seminars and discussions with invited speakers. . BMS 6630-Tumor Biology (3) Pathobiology, biochemistry, and molecular biology of neoplasia; viral and chemical carcino- genesis; immunology and therapy of cancer in man and animals. BMS 6631-Experimental Tumor Biology (2) Prereq: BMS 6630 or consent of instructor. Development of laboratory skills and techniques used in study of various phenomena in tumor biology. Students will work in direct association with members of the BMS 6630 teaching faculty. BMS 6641-Immunopathology (2) Abnormalities and diseases having immunological bases are studied, BMS 6642L-Experimental Immunology (2) Prereq: consent of instructor. Coreq: BMS 6314. Project oriented. Laboratory skills and techniques in immunobiology developed. Each student works in close association with a faculty member. BMS 6645-Pathobiology of Cellular Membranes (2) Prereq: MCB 6401. Discussion on structural and functional changes of membranes involved in disease states. BMS 6646-Experimental Pathology and Immunology: A Rota- tion (2-12; max: 12) Prereq: BMS 6314, 6603 and consent of instructor. Individual investigative projects. Participation in all phases of experimental pathology and immunology. Laboratory training in methodology and data interpretation of basic research. Students specializing in experimental pathology and immunology must spend three terms on this rotation. BMS 6647L-Advanced Methods in Immunology (2) Prereq: consent of instructor. Coreq: BMS 6314. A laboratory course to gain practical experience with methods used in immunology research today. Cell separation and identification techniques, isolation and analysis of protein structure, electrophoretic and chromatographic isolation procedures, hybridoma production and monoclonal antibody screening procedures, and genetic engineering. Clinical Chemistry BMS 6612-Clinical Chemistry and Toxicology (4) Chemical techniques employed in the diagnosis of disease; methods in toxicology. BMS 6613-Clinical Chemistry and Toxicology: A Rotation (2-20; max: 20) Prereq: BMS 6612. Participation in all phases of practical clinical chemistry and toxicology. Chemical method- ology, clinical interpretation and significance of laboratory measurements used in diagnosing diseases. Individual in- vestigative project in clinical chemistry and toxicology. Pathology graduate students specializing in clinical chemistry must spend three terms on this rotation. BMS 6623-Seminars in Clinical Chemistry (1) Prereq: consent of instructor. Required of graduate students in clinical chemistry; open to others by permission of staff. Reports and discussions of current research and clinical literature presented by clinical chemistry staff, invited speakers and graduate students. BMS 7660-Medical Information Systems (2) Systems analysis techniques, both theoretical and practical, applied to the medical database. Communications within health care delivery systems studied. Clinical Immunology BMS 6617C-Clinical Immunology: A Rotation (2-12; max: 12) Prereq: consent of instructor. Coreq: BMS 6314. Individual in- vestigative projects. Laboratory training in the performance and interpretation of clinical imunology laboratory tests. Applica-