CHM 3120C or consent of instructor. Theory of radioactivity,
interaction with matter, and radioactive decay given in suffi-
.cient detail to make the laboratory techniques and practices
thoroughly understood.
GMS 6905-Research in Medical Sciences (1-10; max: 10)
Supervised research other than that for the thesis or disserta-
tion in anatomy, biochemistry, immunology and medical
microbiology, neuroscience, pathology, physiology, pharma-
cology, and veterinary medicine.
GMS 6910-Supervised Research (1-5; max: 5) S/U.
GMS 6920-Clinical Rounds for Graduate Students (1-3; max:
6) Permission of coordinator and clinical instructor necessary.
Graduate students of the medical sciences disciplines will attend
conferences and attend ward rounds with a clinical mentor on
the service of their choice.
GMS 6940-Supervised Teaching (1-5; max: 5) S/U.
GMS 6971-Research for Master's Thesis (1-15) S/U.
GMS 7980-Research for Doctoral Dissertation (1-15) S/U.


MEDICINAL CHEMISTRY
College of Pharmacy
 GRADUATE FACULTY 1982-83
Chairman: N. S. Bodor. Graduate Coordinator: R. J.
Bergeron. Professors: N. S. Bodor; R. H. Hammer; K. V.
Rao; R. Streiff. Associate Professor: R. J. Bergeron.
Assistant Professors: M. James; K. Sloan.
 The College of Pharmacy offers Master of Science in
Pharmacy and Doctor of Philosophy degrees in pharma-
ceutical sciences with specialization in medicinal
chemistry.
 Specific areas include research in pharmaceutical
analysis, drug metabolism, prodrugs, natural product
chemistry, enzyme-substrate binding mechanisms, design
and synthesis of medicinal agents, multiple pulse NMR
techniques, effects of high pressure on biological systems,
and metal chelate design.
 The applicant should have an undergraduate degree
in pharmacy, chemistry, biology, or premedical sciences.
A background in calculus and physical and organic
chemistry is required.
PHA 6354-Natural Medicinal Products 1 (3) Chemistry of com-
pounds derived from plants and animals.
PHA 6355-Natural Medicinal Products II (3) Prereq: PHA
6354.
PHA 6356-Natural Medicinal Products III (2) Prereq: PHA
6355.
PHA 6357L-Natural Medicinal Products 1 (2) Accompanying
laboratory course for PHA 6354. Isolation and identification of
plant and animal products.
PHA 6358L-Natural Medicinal Products II (2) Accompany-
ing laboratory course for PHA 6355. Isolation and identifica-
tion of plant and animal products.
PHA 6445-Drug Design (3) Prereq: PHA 6470. Theoretical
treatment of structure activity relationships and approaches to
drug design.
PHA 6470-Synthetic Medicinal Products I (2) The application
of modern synthetic organic chemistry to the synthesis of
medicinals.
PHA 6471-Synthesis and Modification of Drugs (2)
PHA 6473L-Synthetic Medicinal Products II (2) Accompany-
ing laboratory course for PHA 6471. Synthesis of organic
medicinal compounds.
PHA 6474-Synthetic Medicinal Products III (2)
PHA 6905-Research Procedures in Medicinal Chemistry (1-4)
Prereq: departmental consent. Laboratory research, advanced
discussion, and reading. Research problems of interest to the
student and his program.
PHA 6910-Supervised Research (1-5) S/U.
PHA 6934-Seminar in Medicinal Chemistry (1) Weekly presen-
tation and discussion of research reports based on College pro-
grams or literature.


 MICROBIOLOGY AND CELL SCIENCE / 109

 PHA 6938-Research Seminar (1) Seminar required of graduate
 students in the College of Pharmacy. S/U option.
 PHA 6940-Supervised Teaching (1-5) S/U.
 PHA 6971-Research for Master's Thesis (1-15) S/U.
 PHA 7980-Research for Doctoral Dissertation (1-15) S/U.


 MICROBIOLOGY AND CELL SCIENCE
 College of Agriculture
 GRADUATE FACULTY 1982-83
 Acting Chairman: P. M. Achey. Graduate Coordinator:
 L. 0. Ingram. Graduate Research Professor: R. R.
 Schmidt. Professors: P. M. Achey; H. C. Aldrich; A. S.
 Bleiweis; J. W. Brookbank; G. E. Gifford; J. H. Gregg;
 E. M. Hoffmann; D. H. Hubbell; L. O. Ingram; J. F.
 Preston, III; P. H. Smith. Associate Professors: F. C. Davis,
 Jr.; D. E. Duggan; S. R. Farrah; G. C. Karp; E. P. Previc;
 K. T, Shanmugam; S. G. Zam. Assistant Professors: S. E.
 Coleman;' W. B. Gurley.
 Graduate study is offered leading to the Master of
 Science and Doctor of Philosophy degrees in
 microbiology and cell science, with emphasis in one or
 more of the disciplines of biochemistry, cell biology, and
 microbiology. Instruction and guidance are collaborative
 among faculty in the Colleges of Agriculture, Liberal Arts
 and Sciences, and Medicine.
 Areas of research include anaerobic metabolism;
 biomass conversion and low energy technology; nitrogen
 fixation; membrane and cell wall chemistry and biochem-
 istry; immunology; virology; microbial ecology; bacterial
 and phage genetics; DNA, RNA, and protein synthesis;
 molecular aspects of development of procaryotic and
 eucaryotic systems; cell ultrastructure.,
 Prerequisites for admission to graduate study, in addi-
 tion to those of the Graduate School, are a broad educa-
 tional background including mathematics, physics, and
 chemistry through organic, analytical, and physical
 chemistry; basic courses in botany and zoology; and
 preferably at least one course in microbiology. An
 undergraduate major in physical or chemical science,
 engineering, or general biology is usually acceptable.
 Receipt of an advanced degree requires detailed
 knowledge in microbiology, biochemistry, and
 chemistry; undergraduate deficiencies may necessitate
 additional course work prior to entry into the graduate
 program.
 In addition to the courses listed below, the following
 will be accepted for credits toward graduate degrees in
 Microbiology and Cell Science: BCH 6065, 6206, 6415,
 and BMS 6352.
"MCB 5458-Energy Transformation in Microorganisms (3)
Prereq: CHM 3120, BCH 4313. Energy transformations of
dissimilatory and assimilatory processes in microorganisms with
emphasis on regulation and energy cycles. Application of
microbial energy transformations to low energy technology.
MCB 6315L-Recombinant DNA Techniques (2) Prereq: BCH
6415 and/or BMS 6352 and consent of instructor. Application
of recombinant DNA techniques, agarose gel electrophoresis
and hybridization for the in vitro construction, selection, and
characterization of chimeric E. coli vector plasmids.
MCB 6316-Plasmids, Transposons, and Recombinant DNA
Technology (2) Prereq: BCH 6415 and/or BMS 6352 and con-
sent of instructor. Background and current state of knowledge
of plasmids, select bacteriophage, insertion sequences,
transposons, mobile genetic elements of eucaryotes, and recom-
binant DNA methods.
MCB 6406-Bacterial Cell Surfaces (2) Prereq:. advanced
undergraduate courses in microbiology and biochemistry and
consent of instructor. A comprehensive review of current
knowledge concerning structure, function, and biosynthesis of