140 Y. Yuthavong industrialized countries, including protection of micro-organisms and plants originally occurring in the developing countries, but having been isolated or modified by foreign inventors, pose an important dilemma for the developing countries over policy for most effective use of the biore- sources. To open these resources to the international industrial community would, on the one hand, encourage more effective utilization through bio- technology. On the other hand, such an open policy might inadvertently lead to restriction of use by the developing countries of their own resources in the long run. Depending on the status of biotechnology and bioindustry, each developing country has to find the optimum measures which will allow both the growth of technology and the retention of ownership of its endogenous resources. The use of a few superior resources, say, genetically improved plant species, has a side effect which must not be ignored by the developing countries. As the extent of this use grows, the survival of the various origi- nal genetic resources is threatened. Conservation of the original genetic resources should be an important aim of biotechnology as well as develop- ment and utilization of improved resources. The conservation is important not only for a passive purpose of maintaining the original gene pool, but also for the active purpose of a safeguard against inadvertent loss of genetic characters which might be needed in unforeseen stress situations or in fur- ther improvement of the resources. SAFEGUARDS AGAINST BIOHAZARDS Just as the questions of safety to the public, either from laboratory or field experiments or actual applications in biotechnology, are taken seri- ously in developed countries, so should they also be raised in the develop- ing countries intending to promote their biotechnological capabilities. The developing countries are fortunate in that they can learn from the experi- ence of developed countries. The safety of genetic engineering experiments and genetically engineered microorganisms, for example, has been subject to scientific tests and public debate for over a decade now, and the conclu- sions reached so far should be useful to the developing countries in devising safety guidelines. Ensurance of safe commercial products of genetic engi- neering is a part of necessary development work by the companies which must meet rigorous criteria before the products can be released. The issue of environmental impact of released biotechnology products is being ac- tively examined. Developing countries should take an active interest in these issues, and take precautionary measures as necessary. These issues are