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!-- Gait Analysis in Aged Parkinsonian Mice ( Book ) --
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mods:abstract lang en This study aimed to provide a deeper understanding of the motor impairments related to Parkinson's disease in the literature by analyzing the long-term gait performance of Parkinsonian mice possessing a unique a-syn misfolding and aggregation phenotype (M83+/-). The aim of this thesis was to conduct a comparative analysis of gait patterns between M83+/- mice and a control group at 12 and 52 weeks old. This research endeavor seeked to address the gap in the current literature by providing gait analysis for hemizygous M83+/- mice at 52 weeks of age, as these mice have a known pathological burden at this age and are expected to exhibit gait dysfunction. The gait analysis results at 52 weeks of age show an increase in the average limb stride length variability and average limb ataxia coefficient of M83+/- mice, indicating gait dysfunction. However, no significant differences in several other gait parameters, such as stride length and frequency, were observed at 52 weeks between the two groups. These results are consistent with human PD progression, in which pathological symptoms precede motor decline. These hemizygous mice show slow motor impairment and disease progression, thus making them suboptimal options for studying gait in PD.
mods:accessCondition Copyright Xavier Becsey. Permission granted to the University of Florida to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
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mods:physicalLocation University of Florida
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mods:namePart Becsey, Xavier
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mods:note Awarded Bachelor of Science, magna cum laude, on April 29, 2022. Major: Nutritional Sciences
College or School: Agricultural and Life Sciences
Advisor: Vinata Vedam-Mai. Advisor Department or School: Neurology. Advisor: . Advisor Department or School:
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mods:caption 2023
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mods:topic Undergraduate Honors Thesis/Project
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mods:title Gait Analysis in Aged Parkinsonian Mice
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