I certify that I have read this study and that in my opinion it conforms to acceptable standards of scholarly presentation and is fully adequate, in scope and quality, as a dissertation for the degree of Doctor of Philosophy. P.V. Rao Professor of Statistics This dissertation was submitted to the Graduate Faculty of the College of Health Related Professions and to the Graduate School and was accepted as partial fulfillment of the requirements for the degree of Doctor of Philosophy. August 1995 ___ Dean, College of Health Related Professions Dean, Graduate School