In this study, emotional experience as measured by autonomic responding, facial muscle activity, and verbal report was examined in 12 patients with RHD, 12 patients with LHD, and 24 normal control subjects (NCS) during anticipation of shock and reward. Results revealed that during the shock condition, RHD subjects displayed a deficit in skin conductance responding compared with the NCS, but not compared with the LHD subjects. None of autonomic or facial muscle variables differentiated the reward from the control condition during the reward task. These results are discussed in light of the global and bivalent theories of emotion as well as neuroanatomic correlates of electrodermal activity. vii