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these values in equation A3, we obtain H=-7.19. The critial value of
chi-square with a =0.05 and df = k-1 = 2 from the chi-square table is
5.99. Since the observed H is smaller than 5.99, we accept the null
hypothesis and conclude that there is no significant difference among
the three groups. Thus dose-independent pharmacokinetics can not be
denied at the dose range studied.