Table Al. Fitting of plasma data with various weighting factors.
Weight
Feathering
Log Yi3
0C
ld
2e
Parameter^
P
3743
3341
4228
4075
3585
A
254.3
304
452
318
284
B
48.13
36.25
227
45.1
32.82
IT
0.4773
0.461
0.713
0.562
0.487
a
0.0093
0.0097
0.0744
0.0114
0.09
6
0.0009
0.00075
0.0048
0.0009
0.00074
ssg
81170
122719
17583
41853
90010
Fitting of the plasma data of 1 from dog C by the method of residuals.
Plasma concentrations of 1 were transformed into natural logarithms and fitted by
"Multi" (appendix I) using equal weight for all points.
Q
Plasma data fitted by "Multi" (appendix I) with equal weight for all points.
Plasma data fitted by "Multi" (appendix I) with weight=l, i.e., plasma points were
weighted by 1/Yi values.
e 2
Plasma data fitted by "Milti" (appendix I) with weight=2, i.e., weighted by 1/Yi
values.
^ Paremeters of the equation 2 for intravenously administered buprenorpine (1) in plasma
against time for the 1.439 mg/kg dose in 24.2 kg dog C.
g Unweighted sum of squares.
256