221
Table 7. Continued . .
This biliary clearance was calculated from the expression, f.Cl ,
where f is the fraction of the dose excreted in bile. The biliary
clearance, estimated from a plot of the cumulative amounts of the
systemic metabolite excreted in bile was 300 ml/min, see Fig. 77d. This
clearance estimted from the initial slope was bile flow dependent (Fig.
79a).
'p Percent recoveries of the conjugate in urine and bile obtained from
the quotient of the amounts recovered in urine or bile and the total
infused dose of the conjugate.
^ Apparent volume of distribution of the central compartment estimated
by fitting the post-infusion data to equation 50 by nonlinear least
square regression (Appendix I). The values in parenthesis were
calculated from equation 10, where the values of P, A and B were
obtained through equations 16-18.
r V. was calculated from the ratio of Cl. / r
d tot v