Figure 63. Semi logarithmic plots of the amounts of the hepatically
formed metabolite (M) remaining to be excreted in bile versus time
(Sigma minus plot) following IV infusion of buprenorphine in accordace
with equation 20. a) Sigma minus plot of metabolite in bile of dog E
(Study #9) following 4.8 mg/kg IV infusion of buprenorphine, resulting
in an estimated apparent elimination rate constant of 0.0038/min
(half-life = 181 min). b) Sigma minus plot for the biliary excretion of
metabolite in dog F (Study #10) following 4.0864 mg/kg IV infusion of
buprenorphine. The estimated apparent elimination rate constant was
0.0029/min (half-life = 241 min), c) Sigma minus plot of metabolite in
bile of dog G (Study #11) upon IV infusion of 3.7408 mg/kg dose of
buprenorphine. Estimated apparent excretion rate constant was 0.0026/min
(half-life = 268 min).