Figure 55. Semilogarithmic plots of the amounts of the metabolite (M) remaining to
be excreted in urine versus time (sigma minus plot) following IV infusion of
buprenorphine in accordance with equation 20. a) Sigma minus plot of metabolite in
urine of dog B (Study #7) following 4.6885 mg/kg IV infusion of buprenorphine,
resulting in an estimated apparent rate constant 0.0013/min (half-life = 553 min),
b) Sigma minus plot of metabolite in urine of dog D (Study #8) following 3.847
mg/kg IV infusion dose of buprenorphine. The estimated apparent rate constant was
0.00037/min (half-life = 1877 min), c) Sigma minus plot of the urinary excretion
of metabolite for the 4.8 mg/kg IV infusion dose of buprenorphine in dog E (Study
#9). The estimated apparent rate constant was 0.0034/min (half-life = 203 min), d)
Sigma minus plot of the urinary excretion of metabolite for the 4.0864 mg/kg IV
infusion dose of buprenorphine in dog F (Study #10). The data were fitted to a sum
of two exponentials in accordance with equation 20. The estimated apparent rate
constants were 0.00567/min (half-life = 122 min) and 0.00009/min (half-life = 7700
min) respectively.