e95% Confidence limits were calculated from the t-table at a=0.025 level of significance for (n-2) degrees
of freedom.
f In the estimation of total area under the plasma concentration of buprenorphine against time in accordance
with equation 10, the parameters P and A were obtained through equations 16 and 17. The parameters it anda
were obtained from the computer fit of the post-infusion data to equation 15. The parameters B and g were
obtained from the semilogarithmic plots of the terminal phase plasma data against time. The 95% confidence
intervals for AUC were obtained from the confidence limits estimated for the terminal rate constant assuming
no error in the P, A, ir anda values. See also discussion in the last section under the subheading "Validity
of the terminal rate constant".
^Total clearance was estimated iron the quotient of Dose/AUC where AUC was estimated from the
oo oo
plasma concentrations of buprenorphine. The 95% confidence limits for the total clearances were calculated
from the 95% confidence limits of the AUC values.
^The total clearances were calculated using trapezoidal rule.
lrThe means and standard error of the means for the total clearances were calculated for the bile cannulated
dogs E, F and G only (The other dogs were not bile cannulated).
-*C1q the biliary clearances of buprenorphine as metabolite were estimated from equation 58.
B
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