r,s,t,u percen1- recoveries of buprenorphine and M in urine and bile obtained iron the quotient of the amounts
recovered in urine or bile and the total infused dose of buprenorphine.
v Apparent volume of distribution of the central compartment estimated by fitting the post-infusion data to
either equation 39 (2-compartment model) or 50 (3-compartment model) by nonlinear least square regression
(Appendix I). The values in parenthesis were calculated from equation 10, where the values of P, A and B were
obtained through equations 16-18. The mean and the standard error represents the volumes of distribution
estimated through equation 39 (or 50).
w Vj, the apparent volume of distribution of buprenorphine in the body was calculated from the ratio of
CW 6
x In dogs F, the average terminal phase rate constant (0.000345/min) rather than the estimated terminal rate
constant was used in the estimation of apparent volume of distribution.
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