97
O
-3
Figure 24. Ser logarithmic plots of the amounts (y g) of a)
buprenorphine (1) and b) metabolite (M) excreted in urine per min
( yg/min) plotted against t-mid, the mid point of the urine collection
interval in accordance with the equation:
log AU/ At = (~k'/2.303) t-mid + intercept
For the 1.4171 mg/kg IV bolus dose of buprenorphine in dog A (Study #1,
Table 2), the plot in accordance with the above equation for 1 gave an
apparent rate constant 0.0394/min (half-life = 18 min). For the 1.6369
mg/kg IV bolus dose of buprenorphine in dog B, Study #2, the plot in
accordance with the above equation for M gave an apparent rate constant
of 0.0046/min (half-life = 150 min).