Figure 20. Semi logarithmic plots of the plasma concentrations (ng/ml) of
metabolite (M) against time (min) for the 1.439 mg/kg dose of buprenorphine in
24.2 kg dog C, Study #5. The solid line represents the curve obtained by fitting
the plasma data of M to a sum of three exponentials in accordance with the
equation (2):
_ -0.106 t A -,oc -0.0068 t Mr q -0.000495 t
Cp (ng/ml) = 727 e + 335 e + 46.8 e
The inset is a continuation of the data and the fitted curve on an extended time
scale up tp 2750 min.