Figure 17. Semilogarithmic plots of the plasma concentrations (ng/ml) of
metabolite (M) against time (min) for the 1.6369 mg/kg IV bolus dose of
buprenorphine in 17.6 kg dog B, Study #2. The solid line represents the curve
obtained by fitting the plasma data of M to a sum of three exponentials in
accordance with equation (2):
Cp (ng/ml) = 308 e '191 t + 267.7 e_0'0169 t
+ 33.8 e
-0.000344 t
The inset is the representation of the data and the fitted curve for the initial
period of 750 min.