Figure 14. Semilogarithmic plots of the concentrations (ng/ml) of buprenorphine
(1) in plasma plotted against time (min) for the 0.7542 mg/kg
(O) IV bolus dose of buprenorphine in the bile cannulated dog F (morphine-
buprenorphine interaction study, #17). The 3.7408 mg/kg dose (Study #11, ) was
administered by IV infusion over a period of 162 min. Infusion rate of
buprenorphine as base = 0.5588 mg/min. The superimposition of infusion data on IV
bolus data was effected by the prodedure described in this chapter under the
subheading "Dose-independent pharmacokinetics of buprenorphine". The points ()
represent quotient of the concentrations divided by dose that were calculated on
the premise of IV bolus administration of 3.7408 mg/kg dose of buprenorphine in
accordance with the equation 2. The parameters of the equation 2 were obtained
through equations 15-18. These calculated points were multiplied by 0.2016 =
0.7542/3.7408 to challenge superimposition. The nonparametric rank sum test
(Kruskal-Wallis test, Appendix III; see also reference 59) was used to test the
hypothesis (H') that the dose-normalised plasma concentrations at the above two
dose levels were drawn from identical distributions. The critical value of
chi-square with a =0.05 and df=l is 3.84. The observed H' (=0.053) is less than
3.84. Therefore it can be concluded that there is no difference among the two
groups.