Figure 13. Semilogarithmic plots of the concentrations of buprenorphine (1) in
plasma divided by the dose (mg/kg) plotted against time (min) for the 1.2023 mg/kg
(Study #4, O) and 1.439 mg/kg (Study #5,0) dose of buprenorphine dog C. The
inset is the continuation of data on an extended time scale up to 1500 min. The
nonparametric rank sum test (Kruskal-Wallis test, Appendix III; see also reference
59) was used to test the hypothesis (H') that the dose-normalised plasma
concentrations at the above two dose levels were drawn from identical
distributions. The critical value of chi-square with a =0.05 and df=l is 3.84. The
observed H' (=0.78) is less than 3.84. Therefore it can be concluded that there is
no difference among these two groups.