Table 3. Statistics of the calculated terminal rate constants.
Parameter
Dog A
Dog B
Dog B
Dog C
Dog C
Dog D
Study No.
1
2
3
4
5
6
Dog No.
B364
B344
B344
W444
W444
W4123
a
n
10
10
12
13
10
10
Intercept (ng/ml)b 39.8
54.3
31.2
31.0
45.6
34.3
104 8 min 1 C
5.504
8.36
1.715
9.965
8.77
14.2
tl/2 111111
1259
829
4040
695
791
489
104 s of 8 ^
m
0.526
0.965
0.704
1.76
1.0
1.81
95% Confidence
limits for
the terminal
half-life.6
Upper limit
1615
1129
47000
1136
1074
693
Lower limit
1032
654
2111
501
623
378
95% Confidence
limits for total body clearance
(ml/min)
Lower limit
287
247
22
301
329
334
Upper limit
408
362
313
442
457
446
Number of plasma points.
K Q
' Terminal phase intercepts and rate constants were calculated from the regressions of
the logarithm of plasma concentrations against time.
d Standard errors, s values of the terminal rate constants,e were calculated from the
m # j a
statistics of the regressions of the logarithm of the terminal plasma concentrations
against time (also see reference 59).
0 f
' 95% confidence intervals for the terminal rate constants were calculated from t-table
at a =0.05 level of significance for (n-2) degrees of freedom (see also reference 59).
Cl. was estimated using equations 8 and 9.