55
54
(Appendix I). The outlier was included in all other pertinent
pharmacokinetic analyses and plots, such as excretion rate, sigma minus,
and clearance plots. There were no outliers in the other studies.
Since the triexponential equation 1 adequately described the
post-intravenous bolus injection data (Figs. 4-9), a 3-compartment body
model was the simplest pharmacokinetic model for the disposition of
buprenorphine in dogs. The elimination of buprenorphine could occur from
a central compartment (C), reversibly connected with shallow (S) and
53
deep (D) peripheral compartments (scheme II):
The equation which describes the time course of the IV bolus
administered drug in the central compartment Cp as a function of time t
53
as per scheme 2 is given by
cp = (X0/Vc) [ [ (k21 tt ) (k31 -TT )/(TT a ) (TT B) ] e-7r +
[ (k21 a ) ( a -k31 )/(ir-a)(a-g)] e at +
[(k21 B) (k31 -B )/(a-e ) ( TT B ) ] e"et ] Eq. 4
where Xq (k21 -tt ) (k^^ tt )/Vc(tt a) ( tt -B ) = P Eq. 5
X0 (k21 a ) (a -k31 ) /Vc ( tt a ) ( a -B ) = A Eq. 6
and
XQ (k21 B ) (k31 B ) /Vc (a -B ) ( ir -B ) = B Eq. 7