Figure 10. Representative examples of the plots of the weighted residuals against
log Cpcalc values. These weighted residuals were obtained from the equation (3):
6 ( ^exp ^calc ] 1 ^calc
The calculated plasma values were obtained from the triexponential equation 2
fitted to the plasma data of buprenorphine: a) 1.4171 mg/kg dose study in dog A,
Study #1; b) 1.6369 mg/kg dose study in dog B, Study #2; c) the plasma metabolite
(M) residuals obtained after IV administration of buprenorphine for the 1.2023
mg/kg dose study in dog C, Study #4; d) the plasma metabolite residuals obtained
after IV administration of buprenorphine for the 1.439 mg/kg dose study in dog C,
Study #5.
The observed means, slopes and intercepts of these weighted residuals are
given in Table 2. These parameters were not statistically significantly different
from zero as confirmed by t-test. The random distribution of the residuals above
and below the regression line indicated no bias in the fitting of the chosen
model. The validity of the triexponential curve fitting to the plasma data of the
metabolite is discussed in the text.