Figure 9. Semilogarithmic plots of the concentrations (as ng/ml of base) of
intravenously administered buprenorphine (1) in plasma ( O > Fluorescence
detection; Q Electrochemical detection) against time (min) for the 0.7766 mg/kg
dose in dog D (Study #6, Table 2). The solid line represents the curve obtained by
fitting the plasma data to a sum of three exponentials in accordance with the
equation (2):
Cp (ng/ml) = 2519 e
-0.2473
t A -0.012 t ^ OD -0.00158 t
+ 204 e + 38.6 e
The middle inset is the representation of the data and the fitted curve for the
initial 200 min. The top inset is the plot of the weighted residuals calculated in
accordance with the equation (3) against log fitted concentrations. See fig. 10
for details on the residual plots.