Figure 8. Semilogarithmic plots of the concentrations (as ng/ml of base) of
intravenously administered buprenorphine (1) in plasma against time (min) for the
1.439 mg/kg dose in 24.2 kg dog C (Study #5, Table 2). The solid line represents
the curve obtained by fitting the plasma data to a sum of three exponentials in
accordance with the equation (2):
Cp(ng/ml)
-me -0.562 t ^ _1Q -0.0114 t .c -0.00093 t
4075 e + 318 e + 45 e
The insets are the continuation of the data and the fitted curve for the extended
time scale up tp 3000 min.