Figure 5. Samilogarithmic plots of concentrations (as ng/ml of base) of
intravenously administered buprenorphine (1) in plasma against time (min) for the
1.6369 mg/kg dose in 17.6 kg dog B (Study #2, Table 2). The solid line represents
the curve obtained by fitting the plasma data to a sum of three exponentials in
accordance with the equation (2):
Cp(ng/ml)
010 -0.2632 t i.r -7 -0.01731 t
818.1 e + 435.7 e
-0.000904 t
+ 54.33 e
The inset is a representation of the data and fitted curve for the initial period
of 800 min.