LIST OF FIGURES Figure 1 Typical polygraph tracing from which physiologic data was obtained. Of the 5 parameters monitored, 3, tidal volume, peak expiratory flow rate, and respiratory rate may be read directly from the chart. Figure 2 Response of a normal dog to bronchial challenge with 1 mg hist amine. A represents changes in parameters of respiratory function. = respiratory resistance; O = tidal volume; A = dynamic compliance; A = peak expiratory flow rate; = respiratory rate. B represents changes in arterial blood gases. = pC02 and A = p2 . Figure 3 Response of a normal dog to bronchial challenge with 1 mg hist amine. A represents changes in parameters of respiratory func tions. B represents changes in arterial blood gases. Symbols as in figure 2. Figure 4 Response of a normal dog to bronchial challenge with 50 mg hist amine. A represents changes in parameters of respiratory func tion. B represents changes in arterial blood gases. Symbols as in figure 2. Figure 5 Response of a normal dog to bronchial challenge with 50 mg hist amine. A represents changes in parameters of respiratory func tion. B represents changes in arterial blood gases. Symbols as in figure 2. Figure 6 Response of a normal dog to multiple bronchial challenge with histamine. The initial challenge was performed with 1 mg hist amine and the subsequent challenge with 3 mg histamine. A re presents changes in parameters of respiratory function. B re presents changes in arterial blood gases. Symbols as in figure 2. Figure 7 Response of a normal dog to multiple bronchial challenge with histamine. The initial challenge was performed with 10 mg hist amine and the subsequent challenge with 15 mg histamine. A re presents changes in parameters of respiratory function. B repre sents changes in arterial blood gases. Symbols as in figure 2. vi Page 13 Page 20 Page 22 Page 24 Page 26 Page 28 Page 30